{"id":"W4388852099","doi":"10.1111/all.15949","title":"Clinical and molecular effects of oral <scp>CCR4</scp> antagonist <scp>RPT193</scp> in atopic dermatitis: A Phase 1 study","year":2023,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Atopic dermatitis; Placebo; Adverse effect; Tolerability; Eczema Area and Severity Index; Pharmacodynamics; Internal medicine; Clinical endpoint; Antagonist; Pharmacokinetics; Clinical trial; Gastroenterology; Biomarker; Pharmacology; Immunology; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002783845,0.0002212199,0.0007088585,0.0002200874,0.00006153907,0.00001655993,0.000146725,0.0001871428,0.000008748605],"category_scores_gemma":[0.00153152,0.0002063834,0.0001345808,0.0004067089,0.0002725074,0.00007668636,0.000137553,0.0002556866,0.00005680121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001117346,"about_ca_system_score_gemma":0.0001047284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007359964,"about_ca_topic_score_gemma":0.00007354476,"domain_scores_codex":[0.9980078,0.0003378917,0.0005983508,0.0003979836,0.0002609195,0.0003969966],"domain_scores_gemma":[0.9981164,0.001088092,0.0001186213,0.0003717681,0.00005630714,0.0002488394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003538275,0.004788374,0.9111521,0.0007076263,0.001011319,0.01585978,0.002114714,0.000006505109,0.0009176366,0.0003804454,0.05778592,0.005240167],"study_design_scores_gemma":[0.01621304,0.000963506,0.9615744,0.0002236948,0.0002153574,0.0001557855,0.001599415,0.0003584381,0.00332982,0.0005483439,0.01475754,0.00006068568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952695,0.002069489,0.00002193148,0.0001908765,0.0002618599,0.000653773,0.00001001208,0.0001089003,0.001413692],"genre_scores_gemma":[0.9978122,0.000495029,0.00006699996,0.0009905663,0.00004212579,0.0000813447,0.00005946703,0.00002988427,0.0004223816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05042225,"threshold_uncertainty_score":0.8416072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171930980782784,"score_gpt":0.3329137145837165,"score_spread":0.3157206165054381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}