{"id":"W4388852099","doi":"10.1111/all.15949","title":"Clinical and molecular effects of oral <scp>CCR4</scp> antagonist <scp>RPT193</scp> in atopic dermatitis: A Phase 1 study","year":2023,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Atopic dermatitis; Placebo; Adverse effect; Tolerability; Eczema Area and Severity Index; Pharmacodynamics; Internal medicine; Clinical endpoint; Antagonist; Pharmacokinetics; Clinical trial; Gastroenterology; Biomarker; Pharmacology; Immunology; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347292,0.001411595,0.002030749,0.0004819104,0.000424392,0.0008415474,0.0008242319,0.001214135,0.003008774],"category_scores_gemma":[0.0004762069,0.0005171268,0.001241424,0.0003633754,0.0006729038,0.0006799868,0.0002087692,0.002059232,0.0006966846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007670833,"about_ca_system_score_gemma":0.00112684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000872378,"about_ca_topic_score_gemma":0.002076712,"domain_scores_codex":[0.9995999,0.0001575753,0.00002101516,0.00007272485,0.00006497376,0.00008387184],"domain_scores_gemma":[0.9995653,0.00007073709,0.0001130473,0.00003459455,0.00004300577,0.0001732374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5148665,0.1355551,0.005749147,0.002500289,0.002296893,0.0008491218,0.0003174451,0.002516401,0.1831691,0.0002567234,0.006546456,0.1453769],"study_design_scores_gemma":[0.3328655,0.6367977,0.01559254,0.00006374526,0.0007747657,0.0007721862,0.00005742035,0.001011062,0.009114731,0.0001307822,0.002773965,0.00004548184],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907717,0.004838936,0.000422175,0.0002449318,0.00006992728,0.001662009,0.0008647763,0.00009058647,0.001034987],"genre_scores_gemma":[0.9887536,0.003934706,0.001449482,0.0008319745,0.0001947782,0.001371637,0.001474055,0.00003255262,0.001957187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003008774,"threshold_uncertainty_score":0.01006538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171930980782784,"score_gpt":0.3329137145837165,"score_spread":0.3157206165054381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}