{"id":"W4388852256","doi":"10.1139/cjc-2023-0160","title":"NMR characterization of novel interactions between p97 AAA+ ATPase and the p47 adaptor revealing insights into substrate delivery mechanism","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Mechanism (biology); ATPase; Substrate (aquarium); Signal transducing adaptor protein; Characterization (materials science); AAA proteins; Biophysics; Nanotechnology; Stereochemistry; Crystallography; Biochemistry; Enzyme; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373465,0.00008482931,0.000129101,0.00005459922,0.00009443421,0.00002827362,0.0001211835,0.00007450773,0.00001712169],"category_scores_gemma":[0.00009573575,0.0000702941,0.0000775889,0.0001064014,0.00009749863,0.00001257365,0.00001688748,0.00008961957,7.679494e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002211346,"about_ca_system_score_gemma":0.0004255776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001474716,"about_ca_topic_score_gemma":0.0002250057,"domain_scores_codex":[0.9994107,0.0000217012,0.0002775212,0.00009867435,0.000082231,0.0001091086],"domain_scores_gemma":[0.9991529,0.0000179842,0.0002354352,0.000128685,0.000179334,0.0002856915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005212644,0.000005522157,0.0007703981,0.0000320333,0.00005126332,0.000007348217,0.0001668594,0.00002964119,0.998476,0.00004863077,0.0001442271,0.0002159134],"study_design_scores_gemma":[0.001979427,0.00002917443,0.02013414,0.0001254356,0.00008734042,0.00004939803,0.0004598417,0.000530308,0.9710509,0.0003179639,0.005043088,0.0001929973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986445,0.0001544119,0.0004790243,0.0004558454,0.00007118735,0.00004790383,0.000048814,0.000002509914,0.00009585395],"genre_scores_gemma":[0.9990355,0.00008511769,0.00004973292,0.00008436548,0.0002770684,0.000001898123,0.0001411286,0.00001069402,0.0003144603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02742515,"threshold_uncertainty_score":0.286651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388465247526696,"score_gpt":0.2245891485541583,"score_spread":0.2107044960788914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}