{"id":"W4388853118","doi":"10.1101/2023.11.20.567858","title":"Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"EZH2; PRC2; Epigenetics; Cancer research; Carcinogenesis; Myeloid leukemia; Leukemia; Biology; Downregulation and upregulation; Mutation; Cancer; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008231823,0.0001691381,0.0001483388,0.0002257956,0.0000731426,0.0001520516,0.00006051431,0.0001424586,0.001603526],"category_scores_gemma":[0.00008016494,0.00005589996,0.00008260848,0.000118631,0.0001144153,0.00006354867,0.0001199756,0.0001726506,0.0001962043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171238,"about_ca_system_score_gemma":0.00005828248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002061253,"about_ca_topic_score_gemma":0.0002769016,"domain_scores_codex":[0.999954,0.000006988299,0.000004184904,0.00001121329,0.00001546183,0.000008145945],"domain_scores_gemma":[0.9999781,0.000005853613,0.000005960283,0.000002802595,0.000002464189,0.000004778746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001069841,0.000009700368,0.002180597,0.0000177537,0.000005631431,0.000134256,0.00001006692,0.00009748514,0.995387,0.00008596267,0.00005015804,0.001914446],"study_design_scores_gemma":[0.00001603773,0.0002341426,0.03400137,0.000002389404,0.00002237216,0.001743567,0.00003636617,0.0009416906,0.959901,0.0001501815,0.002948025,0.000002726542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969137,0.0004970322,0.000995307,0.00005617868,0.000006605866,0.00001117611,0.0005481024,0.0000408085,0.000931175],"genre_scores_gemma":[0.9976883,0.0002772413,0.0006600802,0.00002794401,0.000004141787,0.000007694342,0.0004850239,0.000005718866,0.0008438196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603526,"threshold_uncertainty_score":0.005364299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03456426635115951,"score_gpt":0.282268539222316,"score_spread":0.2477042728711565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}