{"id":"W4388865581","doi":"10.1080/10408444.2023.2264327","title":"From cultivation to cancer: formation of <i>N</i> -nitrosamines and other carcinogens in smokeless tobacco and their mutagenic implications","year":2023,"lang":"en","type":"review","venue":"Critical Reviews in Toxicology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Biotech; National Cancer Institute; Genentech; Deutsche Forschungsgemeinschaft; Centers for Disease Control and Prevention; Ontario Genomics Institute; Structural Genomics Consortium; Merck KGaA; Genome Canada; Bayer; Takeda Pharmaceuticals U.S.A.; Pfizer; University of Minnesota; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim; American Lung Association; National Center for Chronic Disease Prevention and Health Promotion; Genentech Foundation","keywords":"Carcinogen; Smokeless tobacco; Chemistry; Nornicotine; Tobacco smoke; Food science; Biochemistry; Toxicology; Biology; Tobacco use; Alkaloid; Medicine; Organic chemistry; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820011,0.0004062384,0.0004700919,0.0006951211,0.000207056,0.0007225406,0.0003178522,0.0006883079,0.001606142],"category_scores_gemma":[0.0001742115,0.0001708619,0.0004629474,0.0006336681,0.0003107788,0.000946414,0.0003506077,0.0007341103,0.0006383407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004372375,"about_ca_system_score_gemma":0.0005215612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104638,"about_ca_topic_score_gemma":0.00182729,"domain_scores_codex":[0.9998502,0.00002331954,0.00001595428,0.00003855096,0.00005462406,0.00001737371],"domain_scores_gemma":[0.9999272,0.00002241846,0.00001652165,0.000002818341,0.0000240381,0.000006891736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002626211,0.0001286337,0.003167508,0.04414336,0.0002696293,0.002314836,0.0009663212,0.001473267,0.214868,0.0177481,0.02176688,0.6928908],"study_design_scores_gemma":[0.000006956592,0.0003936312,0.005508484,0.001935157,0.0001899528,0.004515703,0.0003904288,0.000314206,0.04661332,0.004517305,0.9355698,0.0000449584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005412658,0.9880087,0.001359164,0.0006802296,0.0004679213,0.00001102531,0.00009973143,0.00002327624,0.003937263],"genre_scores_gemma":[0.02062683,0.973119,0.0009542046,0.0005276095,0.0003264734,0.0000140988,0.0001640462,0.000008125073,0.004259563],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001606142,"threshold_uncertainty_score":0.005373061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09907035255563029,"score_gpt":0.4166494675074286,"score_spread":0.3175791149517983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}