{"id":"W4388866319","doi":"10.1158/0008-5472.can-22-2948","title":"Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Hospital for Sick Children; Institute for Work & Health; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Generalitat de Catalunya; University of Pennsylvania; Centres de Recerca de Catalunya; U.S. Department of Defense","keywords":"Synthetic lethality; Biology; Cancer research; Gene knockdown; CRISPR; Regulator; Topoisomerase; Cancer; Gene; DNA repair; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007714728,0.0001364122,0.00015111,0.0002482657,0.0001239424,0.0000473102,0.0001521774,0.0001527188,0.0001196999],"category_scores_gemma":[0.00007545469,0.000137159,0.00005104654,0.0008330519,0.00005963447,0.000008664184,0.0001921617,0.0002471572,0.00004717091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088914,"about_ca_system_score_gemma":0.0003195766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002119698,"about_ca_topic_score_gemma":0.00341303,"domain_scores_codex":[0.9981753,0.0001714515,0.0002087314,0.0005248325,0.0003802924,0.0005393472],"domain_scores_gemma":[0.9992244,0.00002795353,0.00003574588,0.0003582601,0.0002120732,0.0001415921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001465417,0.00004438357,0.000651598,0.00004538869,0.00002004905,0.00001021628,0.0003286616,0.00107699,0.982049,0.0001031437,0.0008917129,0.01463229],"study_design_scores_gemma":[0.0005818909,0.000194739,0.003779138,0.0001471823,0.000006272935,0.00000181348,0.000158803,0.0003992895,0.9796858,0.0005295798,0.01429943,0.0002160129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949496,0.0004864914,0.00009080095,0.003326807,0.000233651,0.000689134,0.00007835207,0.00002441257,0.0001207045],"genre_scores_gemma":[0.9961745,0.001050336,0.00003101297,0.0003558842,0.0002945292,0.0009532906,0.00008064324,0.00003575763,0.001024116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01441628,"threshold_uncertainty_score":0.5593181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655209142719743,"score_gpt":0.4533956754048257,"score_spread":0.2878747611328514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}