{"id":"W4388866319","doi":"10.1158/0008-5472.can-22-2948","title":"Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality","year":2023,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); Hospital for Sick Children; Institute for Work & Health; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"European Regional Development Fund; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Generalitat de Catalunya; University of Pennsylvania; Centres de Recerca de Catalunya; U.S. Department of Defense","keywords":"Synthetic lethality; Biology; Cancer research; Gene knockdown; CRISPR; Regulator; Topoisomerase; Cancer; Gene; DNA repair; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815008,0.0004888102,0.0003875609,0.0002578205,0.0001249249,0.0003870713,0.0002117609,0.0002804192,0.001486739],"category_scores_gemma":[0.0001349318,0.0002019466,0.0003421951,0.0001942495,0.0001859676,0.0001497536,0.0002122989,0.0008909875,0.0004987296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003811854,"about_ca_system_score_gemma":0.0002051813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000599092,"about_ca_topic_score_gemma":0.001054059,"domain_scores_codex":[0.9997784,0.0000347245,0.00002492333,0.00005024531,0.00006395231,0.00004768068],"domain_scores_gemma":[0.9998356,0.00003260529,0.00004767508,0.00002439547,0.00001291826,0.00004681944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004679697,0.0000277974,0.0001325422,0.00002369986,0.000006147976,0.00003828301,0.000005341632,0.00009854847,0.998765,0.00004642088,0.00006208034,0.0007473468],"study_design_scores_gemma":[0.000009617104,0.0003354878,0.002639964,0.000003748329,0.00001066951,0.000295664,0.00001327477,0.001088583,0.9942122,0.0000240372,0.00136253,0.00000417291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904232,0.001697753,0.004245199,0.0001529892,0.00005680149,0.00005529267,0.00120888,0.0004136641,0.00174625],"genre_scores_gemma":[0.9946312,0.0007515276,0.001763453,0.00004888819,0.00000643706,0.00003107881,0.0009678265,0.00003808273,0.001761573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001486739,"threshold_uncertainty_score":0.00497365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1655209142719743,"score_gpt":0.4533956754048257,"score_spread":0.2878747611328514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}