{"id":"W4388869530","doi":"10.1002/jgm.3634","title":"Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians","year":2023,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Clopidogrel; CYP2C19; Medicine; Acute coronary syndrome; Internal medicine; Pharmacogenomics; Unstable angina; Myocardial infarction; Population; Cardiology; Cohort; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005817015,0.0003264613,0.0003051021,0.001175704,0.0004316527,0.000662211,0.0003135465,0.0003077457,0.002081529],"category_scores_gemma":[0.001727629,0.0001549358,0.0006180698,0.001500678,0.0003389893,0.0001161447,0.0002898479,0.0004455491,0.0002350843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172609,"about_ca_system_score_gemma":0.0002529204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004438202,"about_ca_topic_score_gemma":0.002460181,"domain_scores_codex":[0.9995936,0.0001273206,0.00004628166,0.00009356145,0.00007881175,0.00006059869],"domain_scores_gemma":[0.9988297,0.0002661407,0.0004477758,0.0001216005,0.0001814085,0.0001533249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006591164,0.00007524901,0.9906138,0.00003190762,0.0002464266,0.0004495246,0.0002514185,0.0001010955,0.003947122,0.00009124525,0.0001019844,0.003431015],"study_design_scores_gemma":[0.00001081109,0.0001726616,0.9975255,0.000007528908,0.0002144886,0.00070806,0.0001819489,0.0003500363,0.0005287263,0.00005837277,0.0002356033,0.000006299806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998701,0.0001563938,0.0002267199,0.00004143981,0.000007432533,0.00001473474,0.0002932119,0.000007212293,0.0005519651],"genre_scores_gemma":[0.9994003,0.00006317707,0.0001818071,0.00002375173,0.00001142,0.000007260434,0.0001853037,0.000003823686,0.0001231456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004438202,"threshold_uncertainty_score":0.008824706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153917072670721,"score_gpt":0.3034247194355266,"score_spread":0.2818855487088194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}