{"id":"W4388869580","doi":"10.1111/acer.15231","title":"Acetaldehydeâmediated increase in glutamatergic and Nâacetylaspartate neurometabolite levels in the midcingulate cortex of ALDH2*1/*2 heterozygous young adults","year":2023,"lang":"en","type":"article","venue":"Alcohol Clinical and Experimental Research","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto; Centre for Addiction and Mental Health","funders":"Daiichi Sankyo Europe; Yoshitomiyakuhin Corporation; Canadian Institutes of Health Research; School of Medicine, Indiana University; H. Lundbeck A/S; Teijin Pharma; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Shionogi; Eisai; Taiju Life Social Welfare Foundation; SENSHIN Medical Research Foundation; Japan Research Foundation for Clinical Pharmacology; Pfizer; Dainippon Sumitomo Pharma; EA Pharma Co., Ltd.; Novartis Pharma; Otsuka Pharmaceutical; Japan Agency for Medical Research and Development; Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering; Japanese Society of Clinical Neuropsychopharmacology; Eli Lilly and Company; Brain and Behavior Research Foundation","keywords":"Acetaldehyde; Glutamine; Glutamatergic; Internal medicine; Endocrinology; Analysis of variance; Glutamate receptor; Alcohol; Alcohol dependence; Chemistry; Medicine; Ethanol; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004384154,0.0002124477,0.0006517247,0.0004487407,0.0001300127,0.00004321749,0.0001754694,0.000184476,0.00006230327],"category_scores_gemma":[0.0008412182,0.0001525354,0.00008841459,0.001045224,0.0008220439,0.000120189,0.0002825748,0.0008882831,0.00009049319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002676242,"about_ca_system_score_gemma":0.00009778724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009661186,"about_ca_topic_score_gemma":0.0001461679,"domain_scores_codex":[0.9959102,0.001089124,0.0009554385,0.0005942775,0.0007196293,0.0007313898],"domain_scores_gemma":[0.9972824,0.00177082,0.00009757495,0.0003637867,0.00008658765,0.0003988297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006367904,0.001545869,0.8918461,0.0008394755,0.00007680925,0.001660244,0.00651877,0.000002566649,0.08493742,0.0001607848,0.001392815,0.004651238],"study_design_scores_gemma":[0.00893918,0.001018965,0.9836392,0.0003510427,0.00001302934,0.0001076245,0.001102526,0.00111073,0.002821376,0.00004983681,0.0007015624,0.0001448899],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930258,0.003812959,1.169015e-7,0.001441842,0.000129305,0.001229036,0.00002528641,0.00003939413,0.0002962398],"genre_scores_gemma":[0.9942654,0.003656425,0.00001747665,0.001636083,0.00006797803,0.0001360174,0.00003787569,0.00002761524,0.0001551802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09179313,"threshold_uncertainty_score":0.6220213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2557062764181841,"score_gpt":0.5068740817279761,"score_spread":0.251167805309792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}