{"id":"W4388869580","doi":"10.1111/acer.15231","title":"Acetaldehyde‐mediated increase in glutamatergic and <i>N</i>‐acetylaspartate neurometabolite levels in the midcingulate cortex of <i>ALDH2*1/*2</i> heterozygous young adults","year":2023,"lang":"en","type":"article","venue":"Alcohol Clinical and Experimental Research","topic":"Alcohol Consumption and Health Effects","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mental Health Research Canada; University of Toronto; Centre for Addiction and Mental Health","funders":"Daiichi Sankyo Europe; Yoshitomiyakuhin Corporation; Canadian Institutes of Health Research; School of Medicine, Indiana University; H. Lundbeck A/S; Teijin Pharma; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Shionogi; Eisai; Taiju Life Social Welfare Foundation; SENSHIN Medical Research Foundation; Japan Research Foundation for Clinical Pharmacology; Pfizer; Dainippon Sumitomo Pharma; EA Pharma Co., Ltd.; Novartis Pharma; Otsuka Pharmaceutical; Japan Agency for Medical Research and Development; Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering; Japanese Society of Clinical Neuropsychopharmacology; Eli Lilly and Company; Brain and Behavior Research Foundation","keywords":"Acetaldehyde; Glutamine; Glutamatergic; Internal medicine; Endocrinology; Analysis of variance; Glutamate receptor; Alcohol; Alcohol dependence; Chemistry; Medicine; Ethanol; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008860607,0.000311112,0.0002275984,0.000263405,0.0001967718,0.000182283,0.0001049434,0.0001679745,0.001056289],"category_scores_gemma":[0.0001725627,0.0001800979,0.0001461866,0.000109881,0.0002053665,0.0001038549,0.0001268174,0.0002334971,0.000109996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157123,"about_ca_system_score_gemma":0.000119748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005467703,"about_ca_topic_score_gemma":0.005815131,"domain_scores_codex":[0.999949,0.000004640985,0.000005084948,0.0000198392,0.000009049567,0.00001231603],"domain_scores_gemma":[0.9998748,0.000007369678,0.00005412284,0.000007000486,0.00002036243,0.00003623551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006555222,0.000354933,0.2290015,0.00006755842,0.0001256673,0.001495901,0.0005357341,0.00006048786,0.7573259,0.00003555457,0.0001253746,0.004316022],"study_design_scores_gemma":[0.00002927112,0.001053334,0.9710655,0.000002823271,0.0000724895,0.001023452,0.0002631455,0.0001707819,0.0261248,0.00001739509,0.0001706821,0.000006368721],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997962,0.00003952021,0.00006004663,0.000004932929,0.000001255529,0.000003098516,0.00004569039,0.000002565511,0.00004674777],"genre_scores_gemma":[0.9995818,0.0000359484,0.0000996608,0.00001551039,0.0000013668,0.000005175719,0.00006212074,0.000002036031,0.0001964818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005467703,"threshold_uncertainty_score":0.01087177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2557062764181841,"score_gpt":0.5068740817279761,"score_spread":0.251167805309792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}