{"id":"W4388892361","doi":"10.1093/brain/awad398","title":"Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"H2020 Marie Skłodowska-Curie Actions; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; HORIZON EUROPE Framework Programme; Servier; Vetenskapsrådet; Eisai; Dementia Collaborative Research Centres, Australia; National Institute on Aging; National Institute for Health and Care Research; Government of Canada; University College London; University of Southern California; Fondation Jean-Louis Lévesque; EU Joint Programme – Neurodegenerative Disease Research; Northern California Institute for Research and Education; McGill University; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; Pfizer; Biogen; BioClinica; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; National Institute for Social Care and Health Research; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Alzheimer's Research Foundation; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Cohort; Asymptomatic; Internal medicine; Population; Hippocampus; Dementia; Alzheimer's disease; Oncology; Medicine; Psychology; Endocrinology; Pathology; Neuroscience; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005370372,0.0004459668,0.0006351441,0.000819138,0.0002117609,0.00004598941,0.0001859301,0.0003532185,0.0001558506],"category_scores_gemma":[0.001117985,0.0004030888,0.0001512892,0.001338329,0.0001650162,0.0002391646,0.0002258369,0.0006127545,0.0006067892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001336011,"about_ca_system_score_gemma":0.0001510593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004454147,"about_ca_topic_score_gemma":0.0001872249,"domain_scores_codex":[0.9969655,0.0001695626,0.0006758724,0.0008014003,0.0005075247,0.000880114],"domain_scores_gemma":[0.9984661,0.000342618,0.000202086,0.0004466505,0.00009458377,0.0004479442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002770869,0.0006650719,0.7358689,0.0007293964,0.0007828091,0.001345766,0.01592128,0.000001492314,0.1624324,0.001043429,0.03101834,0.04742029],"study_design_scores_gemma":[0.00834889,0.0006745573,0.9588602,0.0003850277,0.00009838978,0.00006232477,0.0006450626,0.0005418552,0.01597765,0.0002368288,0.01347716,0.0006921141],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925397,0.0004269792,0.000005995587,0.003235819,0.0002766453,0.001564696,0.000126082,0.0004503926,0.001373662],"genre_scores_gemma":[0.9951692,0.00021611,0.0002371799,0.0008324292,0.0001755424,0.0001413613,0.0001852982,0.0001019259,0.002940959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2229913,"threshold_uncertainty_score":0.9998421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423144133901928,"score_gpt":0.2635046330807816,"score_spread":0.2392731917417623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}