{"id":"W4388892361","doi":"10.1093/brain/awad398","title":"Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"H2020 Marie Skłodowska-Curie Actions; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; HORIZON EUROPE Framework Programme; Servier; Vetenskapsrådet; Eisai; Dementia Collaborative Research Centres, Australia; National Institute on Aging; National Institute for Health and Care Research; Government of Canada; University College London; University of Southern California; Fondation Jean-Louis Lévesque; EU Joint Programme – Neurodegenerative Disease Research; Northern California Institute for Research and Education; McGill University; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; Pfizer; Biogen; BioClinica; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; National Institute for Social Care and Health Research; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Alzheimer's Research Foundation; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Alzheimer's Drug Discovery Foundation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Cohort; Asymptomatic; Internal medicine; Population; Hippocampus; Dementia; Alzheimer's disease; Oncology; Medicine; Psychology; Endocrinology; Pathology; Neuroscience; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002140987,0.0003798377,0.0003043337,0.0008605472,0.0007150635,0.0004782102,0.000309502,0.0003429802,0.0009357669],"category_scores_gemma":[0.0006215303,0.0002908849,0.0002036037,0.0006797978,0.0002663562,0.0001899399,0.0002551684,0.0003339667,0.00016096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007988696,"about_ca_system_score_gemma":0.0004946289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1563138,"about_ca_topic_score_gemma":0.1345831,"domain_scores_codex":[0.999853,0.00001779522,0.000009554844,0.0000520597,0.00003613213,0.00003147605],"domain_scores_gemma":[0.9998018,0.00001717997,0.00006050591,0.00001632576,0.00003746979,0.00006670571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003637727,0.00004475726,0.9957051,0.000008495223,0.00003310931,0.0004690823,0.0001797885,0.00002342706,0.001507197,0.00001750657,0.00009461668,0.001553278],"study_design_scores_gemma":[0.000006537849,0.00005139215,0.9993643,0.000001979018,0.00001344247,0.0003197428,0.00006732321,0.00003634753,0.00005514993,0.000009075156,0.00007335481,0.000001273984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993622,0.0001763502,0.00002605465,0.00001074925,0.000002059214,0.000007006873,0.0001152471,0.000002154595,0.0002983276],"genre_scores_gemma":[0.9994593,0.0001130476,0.00004272182,0.00001447686,0.000004535174,0.000005254405,0.0001783369,0.000001018856,0.0001813472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1563138,"threshold_uncertainty_score":0.3108079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423144133901928,"score_gpt":0.2635046330807816,"score_spread":0.2392731917417623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}