{"id":"W4388893362","doi":"10.1093/braincomms/fcad312","title":"CSF 14-3-3β is associated with progressive cognitive decline in Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Disease; Biomarker; Alzheimer's disease; Dementia; Medicine; Internal medicine; Cerebrospinal fluid; Pathology; Alzheimer's Disease Neuroimaging Initiative; Amyloid beta; Neuroimaging; Cognitive decline; Psychology; Oncology; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008775594,0.0006451888,0.0006520203,0.001921934,0.0006423447,0.000825523,0.0004628164,0.0006609329,0.001129348],"category_scores_gemma":[0.001994279,0.0002605305,0.0006347235,0.001511905,0.000371495,0.000375677,0.0006331936,0.0004987163,0.000266484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003795106,"about_ca_system_score_gemma":0.0002911201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00550341,"about_ca_topic_score_gemma":0.003504711,"domain_scores_codex":[0.999584,0.00007233214,0.00007430685,0.00009083711,0.0001155699,0.00006292259],"domain_scores_gemma":[0.9983083,0.0002306181,0.0007594181,0.000095499,0.0004394751,0.0001667086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008571017,0.00006493302,0.9925706,0.00003877195,0.0002005139,0.0002952746,0.0001236844,0.00005272829,0.002521955,0.0000200843,0.0001260034,0.003128454],"study_design_scores_gemma":[0.000008079361,0.00008923081,0.9985052,0.00001060332,0.00006093816,0.0004897551,0.00009362355,0.0001472977,0.0003146123,0.00007785247,0.0001972322,0.000005524515],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998252,0.0008974555,0.0001577617,0.00002761364,0.00001352616,0.000007948316,0.0002457082,0.000008845045,0.0003891117],"genre_scores_gemma":[0.999199,0.0001467801,0.0001813299,0.00002220038,0.00001479503,0.000006234554,0.0002467789,0.000002887389,0.0001800445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00550341,"threshold_uncertainty_score":0.01094276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09619557533472507,"score_gpt":0.4056606566329802,"score_spread":0.3094650812982552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}