{"id":"W4388894139","doi":"10.1111/his.15095","title":"<i>IDH1</i>‐mutated Crohn's disease‐associated small bowel adenocarcinomas: Distinctive pathological features and association with <i>MGMT</i> methylation and serrated‐type dysplasia","year":2023,"lang":"en","type":"article","venue":"Histopathology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Department of Molecular Medicine, University of Pavia; Università degli Studi di Pavia; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute; Dipartimenti di Eccellenza; U.S. Department of Defense","keywords":"IDH1; Isocitrate dehydrogenase; IDH2; Pathology; DNA methylation; Cancer research; KRAS; Biology; Medicine; Cancer; Internal medicine; Colorectal cancer; Mutation; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002340352,0.0002343898,0.0002324112,0.0006733602,0.0001834839,0.000360802,0.0001854334,0.0002599618,0.0008841151],"category_scores_gemma":[0.0007158837,0.0001781376,0.0001489793,0.0003901431,0.0003548603,0.0001980644,0.0002625923,0.0001661349,0.000208241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001554372,"about_ca_system_score_gemma":0.00009680667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004535997,"about_ca_topic_score_gemma":0.0005788794,"domain_scores_codex":[0.9998506,0.00002918384,0.00002220325,0.00004811479,0.00002360065,0.00002625378],"domain_scores_gemma":[0.9994627,0.0001163224,0.0002202449,0.00005147624,0.000038833,0.0001104417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005423328,0.00003985238,0.9742345,0.00003012685,0.00003815033,0.001408922,0.00006413034,0.0000396409,0.0209855,0.00001659901,0.00004304912,0.002557175],"study_design_scores_gemma":[0.00001771892,0.0002606743,0.9837479,0.00000445733,0.00003681905,0.01345074,0.00008362569,0.0001805736,0.001977089,0.00001500725,0.0002221218,0.000003329305],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995943,0.0001847969,0.00005631389,0.000005236454,0.000001544884,0.000003030295,0.00002068078,0.000002377882,0.0001318289],"genre_scores_gemma":[0.9997535,0.00005669433,0.0001006051,0.000004843146,0.000004623614,0.000001499121,0.00004522938,7.736724e-7,0.00003217926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008841151,"threshold_uncertainty_score":0.002957642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008429623021828177,"score_gpt":0.2145104965692871,"score_spread":0.206080873547459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}