{"id":"W4388894139","doi":"10.1111/his.15095","title":"<i>IDH1</i>‐mutated Crohn's disease‐associated small bowel adenocarcinomas: Distinctive pathological features and association with <i>MGMT</i> methylation and serrated‐type dysplasia","year":2023,"lang":"en","type":"article","venue":"Histopathology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"Department of Molecular Medicine, University of Pavia; Università degli Studi di Pavia; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute; Dipartimenti di Eccellenza; U.S. Department of Defense","keywords":"IDH1; Isocitrate dehydrogenase; IDH2; Pathology; DNA methylation; Cancer research; KRAS; Biology; Medicine; Cancer; Internal medicine; Colorectal cancer; Mutation; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004628721,0.000290897,0.0002544368,0.0001018898,0.0002478324,0.00004003729,0.0001084669,0.0003886358,0.000007575262],"category_scores_gemma":[0.0007012509,0.0002654361,0.00004868321,0.0002320949,0.0002343428,0.00001527808,0.0001442387,0.000225914,0.00001727303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001006762,"about_ca_system_score_gemma":0.0001173181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008037469,"about_ca_topic_score_gemma":0.0001703554,"domain_scores_codex":[0.9980074,0.0004659234,0.0002393383,0.000685827,0.000171454,0.0004300173],"domain_scores_gemma":[0.9989932,0.00005780358,0.0002354501,0.0002548634,0.0002412884,0.0002173893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001769508,0.00008682068,0.9129563,0.00005390852,0.00004295267,0.003555263,0.0002981607,0.00006932831,0.07813593,0.0001828338,0.002674492,0.0001744879],"study_design_scores_gemma":[0.001043979,0.0002647427,0.9964702,0.000014511,0.0001487525,0.00007349403,0.00008529615,0.0001162928,0.0005809125,0.0002342313,0.0006451275,0.0003225111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976574,0.0007980479,0.00006868128,0.0003106754,0.0001910793,0.0003606577,0.000128316,0.000138771,0.0003463251],"genre_scores_gemma":[0.9966599,0.0001585228,0.0001224047,0.0004588307,0.00007957753,0.00006746594,0.001078221,0.00004374353,0.001331298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08351384,"threshold_uncertainty_score":0.9999798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008429623021828177,"score_gpt":0.2145104965692871,"score_spread":0.206080873547459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}