{"id":"W4388895486","doi":"10.1101/2023.11.20.567923","title":"Seasonal Human Coronaviruses OC43, 229E, and NL63 Induce Cell Surface Modulation of Entry Receptors and Display Host Cell-Specific Viral Replication Kinetics","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Viral entry; Cell culture; Virology; Coronavirus; Biology; Receptor; Cytopathic effect; Viral replication; Cell; Virus; Downregulation and upregulation; Monoclonal antibody; Microbiology; Molecular biology; Coronavirus disease 2019 (COVID-19); Antibody; Gene; Immunology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013637,0.0001844141,0.0002634279,0.0001296781,0.0001017474,0.000327614,0.00008927107,0.000216848,0.0008986455],"category_scores_gemma":[0.0002037587,0.0001129527,0.0002686503,0.0001218928,0.000121511,0.0001525679,0.0001669231,0.000363961,0.0003865645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999955,"about_ca_system_score_gemma":0.00008391166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006837744,"about_ca_topic_score_gemma":0.00073884,"domain_scores_codex":[0.9998098,0.00003376599,0.00002045271,0.00002545536,0.00005790163,0.00005261291],"domain_scores_gemma":[0.9998488,0.00004836142,0.00002505292,0.00002696237,0.0000299469,0.00002085632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003869512,0.00001191799,0.0001660096,0.00000963546,0.00000148748,0.00001592705,0.000009954176,0.00001299607,0.9994925,0.00001177856,0.000007404939,0.0002216815],"study_design_scores_gemma":[0.00001180586,0.0006032432,0.02195252,0.000005186503,0.000008048179,0.0003213648,0.00007819232,0.001134773,0.9748973,0.00002666105,0.0009552352,0.000005649898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971479,0.0005384707,0.0009912696,0.00002491407,0.000009601953,0.00002391537,0.0002709076,0.00002728159,0.0009657702],"genre_scores_gemma":[0.9970306,0.0003035748,0.0009490351,0.00002803962,0.000004589043,0.00003329594,0.0005420143,0.000009703735,0.001099019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008986455,"threshold_uncertainty_score":0.003006339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04184557746933976,"score_gpt":0.2957085966260312,"score_spread":0.2538630191566915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}