{"id":"W4388895540","doi":"10.1021/acsinfecdis.3c00286","title":"Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant <i>Staphylococcus aureus</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Direktion für Entwicklung und Zusammenarbeit; Foreign, Commonwealth and Development Office; Genentech; University of North Carolina at Chapel Hill; Agence Française de Développement; National Institute of Allergy and Infectious Diseases; Pharmaron; Ministerio de Educación, Cultura y Deporte; Monash University; Ontario Genomics Institute; Wellcome Trust; University College London; European Federation of Pharmaceutical Industries and Associations; Bayer; Drugs for Neglected Diseases initiative; Merck KGaA; Ontario Genomics; AstraZeneca; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; McGill University; Bristol-Myers Squibb; Pfizer; University of Queensland; Médecins Sans Frontières","keywords":"Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; Antimicrobial; Antibiotics; Microbiology; Chemistry; Potency; Biology; Bacteria; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002031713,0.0002947038,0.0002840509,0.00009850188,0.0003442947,0.0002049978,0.000504885,0.0001725227,0.00001684378],"category_scores_gemma":[0.0001070603,0.0002839238,0.0001909938,0.0003035088,0.0000956436,0.00001066638,0.0007335171,0.0001301382,0.00005668885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004281433,"about_ca_system_score_gemma":0.0001533552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001321924,"about_ca_topic_score_gemma":0.0003505608,"domain_scores_codex":[0.9983321,0.00009312715,0.0002674268,0.000587276,0.0002313441,0.0004886722],"domain_scores_gemma":[0.998756,0.00004047297,0.0001678405,0.00066727,0.0001404095,0.000228045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001630026,0.0003060791,0.01302272,0.0000829012,0.000365847,0.00003833277,0.00006244927,0.002755106,0.958714,0.0004143949,0.0134495,0.01062565],"study_design_scores_gemma":[0.001990502,0.000515318,0.01289352,0.00008288405,0.0002542702,0.000002370896,0.0006494678,0.0002150741,0.6312773,0.003495684,0.3475932,0.001030379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944919,0.001512587,0.0009787655,0.0003219869,0.000380007,0.0005516268,0.0005234611,0.0001992636,0.001040388],"genre_scores_gemma":[0.9928508,0.002300228,0.00001939578,0.003322142,0.000384023,0.00002966517,0.0006170546,0.00008056081,0.0003961456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3341437,"threshold_uncertainty_score":0.9999613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723848265213719,"score_gpt":0.2782920927899262,"score_spread":0.261053610137789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}