{"id":"W4388895540","doi":"10.1021/acsinfecdis.3c00286","title":"Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant <i>Staphylococcus aureus</i>","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Direktion für Entwicklung und Zusammenarbeit; Foreign, Commonwealth and Development Office; Genentech; University of North Carolina at Chapel Hill; Agence Française de Développement; National Institute of Allergy and Infectious Diseases; Pharmaron; Ministerio de Educación, Cultura y Deporte; Monash University; Ontario Genomics Institute; Wellcome Trust; University College London; European Federation of Pharmaceutical Industries and Associations; Bayer; Drugs for Neglected Diseases initiative; Merck KGaA; Ontario Genomics; AstraZeneca; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; McGill University; Bristol-Myers Squibb; Pfizer; University of Queensland; Médecins Sans Frontières","keywords":"Methicillin-resistant Staphylococcus aureus; Staphylococcus aureus; Antimicrobial; Antibiotics; Microbiology; Chemistry; Potency; Biology; Bacteria; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["open_science"],"consensus_categories":[],"category_scores_codex":[0.0003744224,0.000511906,0.0003838736,0.0005373158,0.0002739449,0.0005347497,0.0008571314,0.0006501327,0.014243],"category_scores_gemma":[0.0005196733,0.0002415037,0.0003491326,0.0006654403,0.0002525409,0.0005345196,0.0005602778,0.0006446575,0.007201029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182161,"about_ca_system_score_gemma":0.0006384717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005052295,"about_ca_topic_score_gemma":0.0008747381,"domain_scores_codex":[0.9996256,0.00003768496,0.00002514356,0.00006325902,0.0001985645,0.00004981412],"domain_scores_gemma":[0.9997155,0.00005087784,0.00007452955,0.00004459833,0.00006864307,0.00004584527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001154153,0.0003684057,0.0007585244,0.001058575,0.00003657905,0.0004338725,0.00008214116,0.0004488927,0.8771846,0.001247872,0.0142666,0.1029598],"study_design_scores_gemma":[0.0002299657,0.001421629,0.003729939,0.00008847369,0.0000600507,0.001239331,0.00004315435,0.001296752,0.832179,0.0004686659,0.1592007,0.00004232717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7034093,0.02744764,0.0719963,0.002954626,0.0009390248,0.001591005,0.05770301,0.02235457,0.1116046],"genre_scores_gemma":[0.7595927,0.02121344,0.0599523,0.0009513156,0.0002043054,0.001039964,0.05732258,0.001811463,0.09791198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9991429,"threshold_uncertainty_score":0.0476476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723848265213719,"score_gpt":0.2782920927899262,"score_spread":0.261053610137789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}