{"id":"W4388895835","doi":"10.1101/2023.11.22.23298878","title":"Uncovering the Shared Genetic Components of Thyroid Disorders and Reproductive Health","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Eston College","funders":"European Regional Development Fund; Eesti Teadusagentuur; Tartu Ülikool; European Commission","keywords":"Pleiotropy; Genome-wide association study; Phenome; Biology; Thyroid; Genetic association; Phenotype; Genetics; Bioinformatics; Evolutionary biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001737516,0.0005778907,0.0006258959,0.001421667,0.0003796094,0.001324369,0.0003704261,0.0004998227,0.005210089],"category_scores_gemma":[0.002792606,0.0002338046,0.001423295,0.001808892,0.0004856632,0.000324623,0.0009393888,0.0005920801,0.000353352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372414,"about_ca_system_score_gemma":0.0005532161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002826774,"about_ca_topic_score_gemma":0.001936668,"domain_scores_codex":[0.999078,0.0004082709,0.00005474829,0.0002696461,0.0001118526,0.00007744507],"domain_scores_gemma":[0.9984692,0.000861467,0.0002979048,0.0002064136,0.00006086383,0.0001041542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001265513,0.00007826131,0.9207149,0.000424365,0.009347761,0.001374079,0.0003069143,0.001909653,0.02429774,0.002229134,0.002810206,0.03524151],"study_design_scores_gemma":[0.0001417885,0.0002008342,0.968694,0.0001339343,0.005134384,0.001918614,0.000418707,0.004915585,0.00548284,0.00735791,0.00556851,0.00003286618],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723654,0.0085848,0.009969329,0.001864081,0.0001409232,0.00002332377,0.00443529,0.0002070195,0.002409802],"genre_scores_gemma":[0.9936254,0.001243488,0.002847663,0.0002008013,0.0001046599,0.000014784,0.001083613,0.00003915392,0.0008402399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005210089,"threshold_uncertainty_score":0.01742953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02957615956216518,"score_gpt":0.287834868986152,"score_spread":0.2582587094239868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}