{"id":"W4388900284","doi":"10.1016/j.cell.2023.10.019","title":"S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis","year":2023,"lang":"en","type":"letter","venue":"Cell","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Aging; GW Pharmaceuticals; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Burroughs Wellcome Fund; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Dana-Farber/Harvard Cancer Center","keywords":"Biology; Staphylococcus aureus; Gene knockdown; Protease; Small interfering RNA; Microbiology; Mediator; Proteases; Scratching; Sensory system; Skin infection; Virulence factor; Virulence; Immunology; Cell biology; RNA; Bacteria; Gene; Genetics; Neuroscience; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008362891,0.0004656281,0.0007318531,0.0002034634,0.001135369,0.001401632,0.0004730266,0.01643108,0.004171862],"category_scores_gemma":[0.00430295,0.0002898639,0.0006559874,0.0001208131,0.00114708,0.001191671,0.0006812194,0.01429711,0.004004119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001863554,"about_ca_system_score_gemma":0.0009098228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00151585,"about_ca_topic_score_gemma":0.001962621,"domain_scores_codex":[0.9993037,0.000215337,0.0000693499,0.00007730787,0.0002152663,0.000119025],"domain_scores_gemma":[0.9984737,0.0008816957,0.0001024448,0.00007199214,0.0002564707,0.0002135888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004218544,0.0001777842,0.002114862,0.0001279462,0.00004262208,0.01285965,0.000198778,0.0001644365,0.006642604,0.006351123,0.9366783,0.03422006],"study_design_scores_gemma":[0.0004734649,0.0004040582,0.003866214,0.0002127013,0.00005074329,0.01063578,0.0006658234,0.001637157,0.003679366,0.01645816,0.9618521,0.00006444476],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.00421465,0.00483868,0.0003288489,0.9656205,0.01899036,0.0000199375,0.0000768941,0.00007214569,0.005838005],"genre_scores_gemma":[0.06992917,0.006149607,0.0008904144,0.818525,0.07655088,0.00009822485,0.00008563502,0.00004618182,0.02772478],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01643108,"threshold_uncertainty_score":0.01395625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365735460623812,"score_gpt":0.2746748117215136,"score_spread":0.2510174571152755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}