{"id":"W4388900284","doi":"10.1016/j.cell.2023.10.019","title":"S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis","year":2023,"lang":"en","type":"letter","venue":"Cell","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institute on Aging; GW Pharmaceuticals; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Burroughs Wellcome Fund; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Dana-Farber/Harvard Cancer Center","keywords":"Biology; Staphylococcus aureus; Gene knockdown; Protease; Small interfering RNA; Microbiology; Mediator; Proteases; Scratching; Sensory system; Skin infection; Virulence factor; Virulence; Immunology; Cell biology; RNA; Bacteria; Gene; Genetics; Neuroscience; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000863781,0.0004426129,0.0007480669,0.0001480473,0.0001487835,0.00004542438,0.0002213134,0.001064907,0.0003035948],"category_scores_gemma":[0.0001072527,0.0003836376,0.0001958434,0.0002008243,0.0002445246,0.00007929508,0.000140098,0.001511929,0.0009109539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003273802,"about_ca_system_score_gemma":0.000218443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006699494,"about_ca_topic_score_gemma":0.000005736247,"domain_scores_codex":[0.9979821,0.0001444325,0.0003336025,0.000683248,0.0003258113,0.0005307925],"domain_scores_gemma":[0.9986858,0.0002021939,0.0001498285,0.0007434401,0.00007481376,0.000143863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004631293,0.00009196466,0.001914885,0.001386841,0.0001204741,0.008745328,0.0003936169,6.822773e-8,0.0005738006,0.000003664333,0.986647,0.00007603433],"study_design_scores_gemma":[0.003170953,0.0002076163,0.00834674,0.001000148,0.00108581,0.0002476162,0.0003796536,0.00004559862,0.01232505,0.00415225,0.9679525,0.001086067],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.3070849,0.00279986,0.0000125769,0.6300389,0.001445398,0.002624499,0.0002116548,0.0006946072,0.05508762],"genre_scores_gemma":[0.1152159,0.0004542318,0.0006115359,0.7881122,0.004874751,0.0004880841,0.00175056,0.0003279444,0.08816478],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1918691,"threshold_uncertainty_score":0.999867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365735460623812,"score_gpt":0.2746748117215136,"score_spread":0.2510174571152755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}