{"id":"W4388902238","doi":"10.1007/s40259-023-00630-5","title":"Efficacy and Safety of Candidate Biosimilar CT-P43 Versus Originator Ustekinumab in Moderate to Severe Plaque Psoriasis: 28-Week Results of a Randomised, Active-Controlled, Double-Blind, Phase III Study","year":2023,"lang":"en","type":"article","venue":"BioDrugs","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto","funders":"Celltrion","keywords":"Ustekinumab; Medicine; Psoriasis Area and Severity Index; Clinical endpoint; Biosimilar; Dosing; Adverse effect; Randomized controlled trial; Psoriasis; Tolerability; Internal medicine; Dermatology; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001661106,0.0003926819,0.001473856,0.0005322935,0.0001293915,0.00001991681,0.0003186022,0.0002665096,0.00007587575],"category_scores_gemma":[0.0003729264,0.0003031415,0.0001913711,0.0009531698,0.0002445491,0.000096257,0.0002002303,0.0003592908,0.00002597159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007088396,"about_ca_system_score_gemma":0.0001617998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005211662,"about_ca_topic_score_gemma":0.0002453225,"domain_scores_codex":[0.9967947,0.0006460561,0.001177886,0.0006997507,0.0001251358,0.0005564691],"domain_scores_gemma":[0.9977064,0.001177675,0.0003682094,0.0004917154,0.0001506869,0.0001053107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9708815,0.001703028,0.00006996475,0.00004289368,0.001219016,0.00004067534,0.001678055,0.00003610981,0.01743956,0.00008598217,0.001262679,0.00554055],"study_design_scores_gemma":[0.9095122,0.00222271,0.0004390168,0.0001039162,0.0004383072,0.000008593705,0.001755833,0.00008279959,0.08051165,0.00002285006,0.00452345,0.000378702],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993409,0.0004862133,0.00002114077,0.0007897529,0.0006749753,0.003450375,0.000701561,0.0000578387,0.0004091708],"genre_scores_gemma":[0.9986297,0.0003059056,0.0001420115,0.00006628539,0.00003286802,0.0001392816,0.00007320533,0.00002464028,0.0005861078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06307209,"threshold_uncertainty_score":0.9999421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04463726408912411,"score_gpt":0.3397974502253265,"score_spread":0.2951601861362024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}