{"id":"W4388906326","doi":"10.26508/lsa.202302211","title":"Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation","year":2023,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Université du Québec à Trois-Rivières","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Canada Foundation for Innovation; Canada Research Chairs; Government of Canada","keywords":"Sting; Thrombopoiesis; Platelet; Cell biology; Megakaryocyte; Thrombopoietin; Platelet activation; Signal transducing adaptor protein; Stimulator of interferon genes; Signal transduction; Biology; Chemistry; Immunology; Innate immune system; Immune system; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007619093,0.0001740363,0.0001208232,0.0001193286,0.00008827362,0.0001834439,0.00007812138,0.0002053426,0.000911814],"category_scores_gemma":[0.00009260092,0.00007747506,0.0001233171,0.00009014618,0.0001072769,0.0001433442,0.0002112066,0.0005241768,0.0002714847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265158,"about_ca_system_score_gemma":0.0000904655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009506063,"about_ca_topic_score_gemma":0.0001894203,"domain_scores_codex":[0.9999425,0.00001143803,0.000005160796,0.000009186262,0.00001754715,0.00001417871],"domain_scores_gemma":[0.9999543,0.000009398641,0.00001166269,0.000008504985,0.000004503805,0.00001150167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002877885,0.000004388328,0.00008569085,0.00001012739,0.000001644929,0.0000462365,0.000008271757,0.00001080652,0.9984837,0.0001704363,0.0000149976,0.001134893],"study_design_scores_gemma":[0.00001964147,0.0002935113,0.006697772,0.000007233304,0.00001668836,0.0005802957,0.00002058814,0.0004877359,0.9878317,0.0001556113,0.003886704,0.00000247577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854739,0.002830764,0.007620825,0.0002216745,0.00004270783,0.00003528745,0.0001984621,0.0001139775,0.003462244],"genre_scores_gemma":[0.9927281,0.0009300233,0.003713937,0.00008423662,0.00001538768,0.00002980869,0.0002641855,0.00001393523,0.002220486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000911814,"threshold_uncertainty_score":0.003050268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04630722724906514,"score_gpt":0.2980253198974391,"score_spread":0.251718092648374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}