{"id":"W4388906467","doi":"10.1101/2023.11.21.568176","title":"Cohesin composition and dosage independently affect early development in zebrafish","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Marsden Fund","keywords":"Cohesin; Zebrafish; Biology; Cell biology; Chromatin; Wnt signaling pathway; Mutant; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217092,0.0006137547,0.0002722618,0.0006621728,0.0002610208,0.0003316117,0.0003106917,0.0004556819,0.001925101],"category_scores_gemma":[0.0001469206,0.000406061,0.000298458,0.0001694002,0.0004563696,0.0002202325,0.0005345206,0.0005284895,0.0004895595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001052362,"about_ca_system_score_gemma":0.0004155011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005471427,"about_ca_topic_score_gemma":0.01004727,"domain_scores_codex":[0.9998381,0.00001105814,0.00001339705,0.00004229061,0.00006777052,0.00002731529],"domain_scores_gemma":[0.9997974,0.00003972529,0.00007729076,0.0000212607,0.00002178897,0.0000425764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004004317,0.000002555221,0.0001334214,0.00001062295,0.000002128595,0.00004227898,0.000008643236,0.00005488882,0.9991296,0.00006794154,0.00001953321,0.0004883056],"study_design_scores_gemma":[0.00002630278,0.0001340766,0.01102469,0.00001223035,0.00003176626,0.0001975024,0.00002879188,0.0007895666,0.985565,0.00009861063,0.002075166,0.00001635249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922759,0.0009778967,0.002330993,0.0001212051,0.00002645348,0.00002535959,0.001146574,0.0002098555,0.00288579],"genre_scores_gemma":[0.9834427,0.0005275017,0.002361723,0.00009178361,0.000006006623,0.00004426251,0.000637227,0.000178017,0.01271078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005471427,"threshold_uncertainty_score":0.01087916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00967979182299093,"score_gpt":0.2086750761665966,"score_spread":0.1989952843436057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}