{"id":"W4388914312","doi":"10.1016/j.bbamcr.2023.119639","title":"Proline and dihydroorotate dehydrogenase promote a hyper-proliferative state and dampen ferroptosis in cancer cells by rewiring mitochondrial redox metabolism","year":2023,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dihydroorotate dehydrogenase; Cell biology; Mitochondrion; Cancer cell; Chemistry; Cell growth; Biology; Oxidative stress; Carcinogenesis; Reactive oxygen species; Biochemistry; Cancer; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005184629,0.001032916,0.001197079,0.001339932,0.0002021387,0.0007611753,0.0007172139,0.001008669,0.002097911],"category_scores_gemma":[0.0005427322,0.0002615457,0.0003133765,0.001305711,0.0004923271,0.0007983035,0.0005019844,0.002063523,0.001580224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005874965,"about_ca_system_score_gemma":0.0006643457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005563,"about_ca_topic_score_gemma":0.003319965,"domain_scores_codex":[0.9999082,0.00001341983,0.00001455516,0.00001928954,0.00003342807,0.00001114117],"domain_scores_gemma":[0.9998083,0.0000839194,0.00002661149,0.000007568321,0.00005208215,0.0000215633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001955935,0.00007362827,0.0001430312,0.009066405,0.0001131266,0.0001991698,0.000039575,0.0003335961,0.003544969,0.00420128,0.04687441,0.9352153],"study_design_scores_gemma":[0.00006117467,0.0001252698,0.0006154458,0.001236974,0.0001312184,0.0006050311,0.00003228653,0.00008504584,0.001702101,0.001771615,0.9936157,0.00001810095],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000134055,0.9983077,0.000174047,0.0003457847,0.0003129343,0.00000398268,0.00002496695,0.000009292165,0.0006871856],"genre_scores_gemma":[0.0009559159,0.9971043,0.0002443477,0.0003271964,0.0002256782,0.000007989734,0.00003648979,0.000002282557,0.001095786],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002097911,"threshold_uncertainty_score":0.007018209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0577032280511031,"score_gpt":0.3887103435533047,"score_spread":0.3310071155022016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}