{"id":"W4388922092","doi":"10.1002/pd.6469","title":"Current controversy in prenatal diagnosis: The use of cfDNA to screen for monogenic conditions in low risk populations is ready for clinical use","year":2023,"lang":"en","type":"review","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Prenatal diagnosis; Population; Pregnancy; Argument (complex analysis); Fetus; Risk assessment; Pediatrics; Obstetrics; Intensive care medicine; Internal medicine; Genetics; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1056571,0.0007273139,0.002006956,0.003402913,0.003618813,0.009476264,0.004317088,0.01962326,0.007434657],"category_scores_gemma":[0.2236856,0.0008643038,0.001585448,0.001926851,0.02292446,0.01669873,0.005316634,0.02793819,0.003142083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005718527,"about_ca_system_score_gemma":0.008254998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003761012,"about_ca_topic_score_gemma":0.002896102,"domain_scores_codex":[0.9510309,0.0248764,0.005575848,0.005862501,0.01093551,0.001718825],"domain_scores_gemma":[0.7027177,0.2401707,0.007525217,0.006034164,0.03695004,0.00660223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004808967,0.0001165388,0.005398714,0.003776444,0.0001492293,0.001064652,0.005451673,0.0002840158,0.001288566,0.1393554,0.3785112,0.4641227],"study_design_scores_gemma":[0.0001242557,0.0002371544,0.003936974,0.0148029,0.0001627245,0.002543798,0.008179677,0.0004996423,0.0008072609,0.1353554,0.8331655,0.0001848151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.0008245605,0.04562287,0.001112246,0.9413124,0.008477864,0.00001020157,0.00004603762,0.00002653569,0.002567335],"genre_scores_gemma":[0.07256833,0.1256933,0.007373889,0.7357025,0.05514093,0.0001229086,0.0002154338,0.0001485703,0.003034269],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1056571,"threshold_uncertainty_score":0.5587749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4094040047884643,"score_gpt":0.4850536384238029,"score_spread":0.07564963363533861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}