{"id":"W4388928854","doi":"10.1080/14756366.2023.2284119","title":"Inhibition of pathogenic bacterial carbonic anhydrases by monothiocarbamates","year":2023,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Neisseria gonorrhoeae; Enterococcus faecium; Bacteria; Microbiology; Enzyme; Growth inhibition; Chemistry; In vitro; Antibiotics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113954,0.0003893117,0.0002378053,0.0001818469,0.0001064882,0.0001255398,0.0001901499,0.0002053831,0.001006835],"category_scores_gemma":[0.0001609667,0.0001025327,0.0002028374,0.0001472097,0.000148451,0.00009285434,0.0001396759,0.0003579272,0.0001798492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001667963,"about_ca_system_score_gemma":0.0002314522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009593346,"about_ca_topic_score_gemma":0.003221411,"domain_scores_codex":[0.9999071,0.00002111848,0.000008040759,0.00001464861,0.00002991792,0.00001924239],"domain_scores_gemma":[0.9999163,0.0000311713,0.00001920522,0.000006753983,0.00001162026,0.00001494019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451644,0.00006219621,0.0002109829,0.0002000137,0.00001694942,0.00007255618,0.00001515558,0.0003274565,0.9941857,0.00008216863,0.00006341112,0.004618203],"study_design_scores_gemma":[0.00004421614,0.001838089,0.003271127,0.00001358896,0.00002711403,0.0002535883,0.00001427536,0.0006376035,0.9907948,0.00004044655,0.003057481,0.000007695757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795796,0.01182935,0.002878628,0.0001796876,0.00006339047,0.0001241795,0.0003054559,0.0001101276,0.004929568],"genre_scores_gemma":[0.9899936,0.005497604,0.002554371,0.00005347545,0.00001741247,0.0000432304,0.0002149152,0.000006756601,0.001618649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006835,"threshold_uncertainty_score":0.003368199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00750396726650443,"score_gpt":0.2297798373809382,"score_spread":0.2222758701144337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}