{"id":"W4388933833","doi":"10.1101/2023.11.23.566885","title":"Immuno-informatics Study Identifies Conserved T Cell Epitopes in Non-structural Proteins of Bluetongue Virus Serotypes: Formulation of Computationally Optimized Next-Generation Broad-spectrum Multiepitope Vaccine","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University","keywords":"Epitope; Immunogenicity; Biology; Virology; Antigenicity; Reverse vaccinology; Conserved sequence; Computational biology; Antigen; Peptide sequence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223968,0.0004891083,0.0004772134,0.0002094199,0.0003290523,0.0003187799,0.0004813482,0.0003463528,0.002056433],"category_scores_gemma":[0.0002623601,0.0002448488,0.0004329923,0.0001794258,0.0001544349,0.0003078229,0.0002566323,0.0005359654,0.0002443036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004728384,"about_ca_system_score_gemma":0.000639932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002775274,"about_ca_topic_score_gemma":0.003587846,"domain_scores_codex":[0.9999264,0.00001369954,0.000002875181,0.00001208063,0.00002030826,0.00002466887],"domain_scores_gemma":[0.999935,0.00002220087,0.000009553077,0.000004127719,0.0000164828,0.0000126031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004571038,0.0004158849,0.005398495,0.0002235429,0.00009203231,0.0004395391,0.0000567816,0.8970428,0.08179823,0.001981174,0.001092124,0.01100238],"study_design_scores_gemma":[0.00004140851,0.0002093728,0.0008359457,0.000006671017,0.00002273162,0.00003411564,0.00003158948,0.9883155,0.009678548,0.0003081873,0.000508934,0.000007036556],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780576,0.0004859205,0.01658914,0.0001712822,0.00003473361,0.00005117116,0.0002707863,0.0001732826,0.004166102],"genre_scores_gemma":[0.9830775,0.0003236468,0.0151065,0.00006746875,0.000006255709,0.00008584747,0.0004728163,0.00005248021,0.000807613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002775274,"threshold_uncertainty_score":0.006879389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03241765829463135,"score_gpt":0.2347470249884544,"score_spread":0.2023293666938231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}