{"id":"W4388933833","doi":"10.1101/2023.11.23.566885","title":"Immuno-informatics Study Identifies Conserved T Cell Epitopes in Non-structural Proteins of Bluetongue Virus Serotypes: Formulation of Computationally Optimized Next-Generation Broad-spectrum Multiepitope Vaccine","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University","keywords":"Epitope; Immunogenicity; Biology; Virology; Antigenicity; Reverse vaccinology; Conserved sequence; Computational biology; Antigen; Peptide sequence; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005506171,0.000468075,0.0008184278,0.0001602395,0.0001490502,0.0001917796,0.0005896356,0.0002993183,0.00005407943],"category_scores_gemma":[0.0001857512,0.0002831538,0.0002032347,0.0007639798,0.00005424561,0.0004617233,0.0004311604,0.0003311757,0.00001419957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238362,"about_ca_system_score_gemma":0.0001510653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002458878,"about_ca_topic_score_gemma":0.0008981613,"domain_scores_codex":[0.9968896,0.0002241327,0.001472231,0.0005167878,0.0005345462,0.0003627202],"domain_scores_gemma":[0.997551,0.0001833947,0.001221014,0.0002994561,0.0006386319,0.0001065393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001686102,0.0003403457,0.03895452,0.0002928433,0.0001033559,0.000007470354,0.000136632,0.007920332,0.9520268,0.00002182509,0.00002090789,0.000006296566],"study_design_scores_gemma":[0.0007810586,0.0002446953,0.7254812,0.0001554869,0.00005913506,8.607324e-9,0.00008883756,0.0166965,0.2561318,0.000004529179,0.000003081524,0.0003537213],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959518,0.0002239867,0.00008153049,0.00006529127,0.0003694123,0.002653082,0.0005174298,0.0001364782,9.639737e-7],"genre_scores_gemma":[0.9978207,0.00009581363,0.00162974,0.00002291979,0.0001846496,0.0002053511,0.00002373462,0.00001385166,0.000003266561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6958951,"threshold_uncertainty_score":0.9999621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03241765829463135,"score_gpt":0.2347470249884544,"score_spread":0.2023293666938231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}