{"id":"W4388938516","doi":"10.12688/wellcomeopenres.20385.1","title":"Phenotypes associated with genetic determinants of type I interferon regulation in the UK Biobank: a protocol","year":2023,"lang":"en","type":"preprint","venue":"Wellcome Open Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University; Population Health Research Institute","funders":"Health Data Research UK; Medical Research Council; National Institutes of Health; National Institute for Health and Care Research; University of Edinburgh; Wellcome; Canadian Institutes of Health Research; Guarantors of Brain; Wellcome Trust; Alzheimer's Society; Ministère de la Santé; Ministère de la Santé et des Services sociaux; Scottish Government","keywords":"Biobank; Interferon; Genetics; Interferon type I; Biology; Minor allele frequency; IRF5; Allele; Phenotype; Genome-wide association study; Single-nucleotide polymorphism; Population; Genetic association; Disease; Human genetics; Gene; Bioinformatics; Immunology; Medicine; Genotype; Allele frequency; Innate immune system; Interferon regulatory factors; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0331336,0.0012738,0.00222471,0.006534274,0.003337922,0.003999655,0.002856968,0.003075516,0.1749768],"category_scores_gemma":[0.07474913,0.001828372,0.001998843,0.0054432,0.001604372,0.00253056,0.005172006,0.002129307,0.03687047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003894423,"about_ca_system_score_gemma":0.01553861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004473707,"about_ca_topic_score_gemma":0.007951851,"domain_scores_codex":[0.98334,0.00691765,0.00523991,0.001679907,0.001749276,0.001073271],"domain_scores_gemma":[0.9387984,0.02194809,0.005390885,0.01201,0.01709722,0.004755377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01936267,0.001516277,0.01469831,0.04561887,0.0004354137,0.003428967,0.007877615,0.001280835,0.009020075,0.0132595,0.7131339,0.1703675],"study_design_scores_gemma":[0.005377158,0.001083335,0.0391517,0.01148891,0.0002479796,0.001065747,0.002121931,0.0005441541,0.002411892,0.004374055,0.931869,0.0002642107],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01406538,0.001410209,0.02106984,0.003587423,0.0007947314,0.7123482,0.2230405,0.001537812,0.02214582],"genre_scores_gemma":[0.008318954,0.001309288,0.02949265,0.001503343,0.0002263367,0.8802236,0.06968018,0.0002247037,0.009021007],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1749768,"threshold_uncertainty_score":0.5853555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1885757017393963,"score_gpt":0.4261913389508026,"score_spread":0.2376156372114064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}