{"id":"W4388939246","doi":"10.1038/s42255-023-00926-4","title":"Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome","year":2023,"lang":"en","type":"article","venue":"Nature Metabolism","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Brock University; University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Cardiolipin; Peroxidase; Biochemistry; Chemistry; Cytochrome c; Lipid peroxidation; Mitochondrion; Phospholipid; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000222215,0.0004294919,0.0002573603,0.0008078527,0.0002883138,0.000310734,0.0003653017,0.0009102793,0.001168903],"category_scores_gemma":[0.0007189973,0.0001921143,0.0001752502,0.0003911063,0.0006544418,0.0003008388,0.0003410277,0.0006701148,0.0002813498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187208,"about_ca_system_score_gemma":0.0001292035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000290411,"about_ca_topic_score_gemma":0.0001317913,"domain_scores_codex":[0.9998,0.00003769775,0.00002415294,0.00004486147,0.00006322332,0.00003004813],"domain_scores_gemma":[0.9995537,0.0001707447,0.00009530023,0.00003947552,0.00004350494,0.00009715892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001712744,0.00006902808,0.02339027,0.0001876711,0.00008330378,0.05378767,0.0002656195,0.0003353239,0.9032183,0.002505165,0.0006728708,0.0137721],"study_design_scores_gemma":[0.00009952403,0.0006925141,0.1389018,0.00003018145,0.000147122,0.1771692,0.0002388822,0.003352037,0.6706262,0.005108663,0.00359188,0.00004200726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996269,0.0009840551,0.001327597,0.0002444028,0.00004606452,0.000004424781,0.00009110647,0.00006106621,0.0009721879],"genre_scores_gemma":[0.9993345,0.0001762515,0.0002336891,0.00001724285,0.00002324527,9.813737e-7,0.00003089211,0.000007459225,0.0001756791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168903,"threshold_uncertainty_score":0.003910363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006593599914129823,"score_gpt":0.2364924256882014,"score_spread":0.2298988257740716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}