{"id":"W4388945218","doi":"10.3389/fimmu.2023.1291649","title":"Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?","year":2023,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Immunosuppression; Immune system; Immunology; Medicine; Regulatory T cell; Transplantation; Cell therapy; Immune tolerance; Stem cell; Biology; T cell; IL-2 receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001940126,0.0005631773,0.001042428,0.0009402636,0.0003147727,0.002362984,0.0006729432,0.001557902,0.00218495],"category_scores_gemma":[0.001700125,0.0002549315,0.0005722405,0.0006955831,0.001552104,0.004566662,0.0006192538,0.002888677,0.001065092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005601205,"about_ca_system_score_gemma":0.0007790137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004650643,"about_ca_topic_score_gemma":0.0007356731,"domain_scores_codex":[0.9996351,0.0001118474,0.00003707252,0.00005125843,0.0001286979,0.00003601676],"domain_scores_gemma":[0.9989567,0.0005777013,0.00009657779,0.00005481028,0.0002109704,0.0001031546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005499205,0.000132893,0.00295423,0.0107713,0.0001741499,0.0005243988,0.0005263925,0.0008059564,0.02311119,0.02975019,0.04589428,0.8848051],"study_design_scores_gemma":[0.00004187076,0.0005557818,0.005023206,0.003660037,0.0002313434,0.002315755,0.0009468982,0.0007077818,0.009695668,0.04276526,0.933951,0.0001053817],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001384564,0.9885329,0.001588148,0.006498257,0.0009134215,0.00000470427,0.00004518992,0.00002123172,0.001011546],"genre_scores_gemma":[0.01075695,0.9793046,0.001820073,0.004256082,0.002594723,0.00002109863,0.0001013933,0.00001528664,0.00112977],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002362984,"threshold_uncertainty_score":0.01026052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438550269566817,"score_gpt":0.2807881347259036,"score_spread":0.2564026320302355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}