{"id":"W4388947034","doi":"10.1186/s12974-023-02963-y","title":"Naïve Huntington’s disease microglia mount a normal response to inflammatory stimuli but display a partially impaired development of innate immune tolerance that can be counteracted by ganglioside GM1","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Glycomics Network; Canadian Institutes of Health Research; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Microglia; Neuroinflammation; Innate immune system; TLR2; Immunology; TLR4; Inflammation; Biology; Pathogenesis; Immune system; Cell biology; Medicine; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007990442,0.0003814206,0.0004656697,0.00058448,0.0002653307,0.0001637308,0.0005684422,0.00005885944,0.0000242875],"category_scores_gemma":[0.00293589,0.0003687654,0.0002008408,0.0007332495,0.0001038417,0.0005554588,0.0001986867,0.000287078,0.00003517402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124052,"about_ca_system_score_gemma":0.0008565861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008013965,"about_ca_topic_score_gemma":0.000023292,"domain_scores_codex":[0.9955274,0.0007328878,0.001522623,0.0004544765,0.001227041,0.0005356047],"domain_scores_gemma":[0.9967576,0.0005270557,0.001335358,0.0004146434,0.0004891594,0.0004762046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004181939,0.000125529,0.003050353,0.00008873345,0.00001958657,0.0002769462,0.002104935,0.00805411,0.98124,0.000006514734,0.0005105268,0.0003407989],"study_design_scores_gemma":[0.0009352023,0.0001585664,0.25622,0.0001541429,0.000037205,0.00002307563,0.00008022186,0.001764025,0.7396365,0.000007676023,0.0007458915,0.0002375294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963381,0.00003080964,0.0001275883,0.002107918,0.0005246268,0.0006137299,0.0001786875,0.00007314191,0.00000538109],"genre_scores_gemma":[0.9990371,0.00002302728,0.0002031413,0.0003499973,0.00009389423,0.0000398985,0.00001914861,0.00006340336,0.0001703998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2531696,"threshold_uncertainty_score":0.9998764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414254375436284,"score_gpt":0.2670720757063249,"score_spread":0.2429295319519621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}