{"id":"W4388948773","doi":"10.1016/j.neubiorev.2023.105479","title":"Neuroactive steroids and Parkinson’s disease: Review of human and animal studies","year":2023,"lang":"en","type":"review","venue":"Neuroscience & Biobehavioral Reviews","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Neuroactive steroid; Pregnenolone; Dehydroepiandrosterone; Androstenediol; Neuroprotection; Estrogen; Parkinson's disease; Dopamine; Hormone; Testosterone (patch); Androgen; Medicine; Internal medicine; Disease; Endocrinology; Neuroscience; Psychology; Steroid; GABAA receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009135433,0.00117059,0.002602868,0.003534134,0.0002943416,0.001283807,0.001051097,0.001246911,0.004032114],"category_scores_gemma":[0.0009298676,0.0004187123,0.0009072886,0.004247468,0.0005664906,0.001180955,0.0007477899,0.00142851,0.001405324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005757103,"about_ca_system_score_gemma":0.001739025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002747324,"about_ca_topic_score_gemma":0.005851639,"domain_scores_codex":[0.9997401,0.00003631839,0.00005704435,0.00004672906,0.00009927226,0.0000205028],"domain_scores_gemma":[0.9994667,0.0002892814,0.00008870317,0.00001436905,0.0001072913,0.00003367981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000266025,0.0001206216,0.0002795319,0.04797754,0.0002882226,0.0002119143,0.00007664267,0.0002928503,0.001851772,0.001446986,0.01979366,0.9273942],"study_design_scores_gemma":[0.0001103792,0.0002930553,0.002634572,0.01679777,0.001157194,0.001775162,0.0001557977,0.0001198636,0.0007184824,0.001795946,0.9743905,0.00005129787],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004843233,0.9996405,0.00002602026,0.00005775496,0.00004187525,0.000002996841,0.00001748886,0.000002561403,0.0001624002],"genre_scores_gemma":[0.0002699211,0.9994085,0.0000767938,0.00006233748,0.00005278378,0.000003343656,0.00001494504,5.493724e-7,0.0001108788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004032114,"threshold_uncertainty_score":0.01348871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3022944263570107,"score_gpt":0.4802829398123567,"score_spread":0.177988513455346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}