{"id":"W4388951814","doi":"10.1136/bmjopen-2023-073120","title":"Evaluating niraparib versus active symptom control in patients with previously treated mesothelioma (NERO): a study protocol for a multicentre, randomised, two-arm, open-label phase II trial in UK secondary care centres","year":2023,"lang":"en","type":"article","venue":"BMJ Open","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"University of Southampton; Asthma and Lung UK; National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Mesothelioma; Clinical endpoint; Internal medicine; Oncology; Response Evaluation Criteria in Solid Tumors; Peritoneal mesothelioma; PARP inhibitor; Progression-free survival; Surrogate endpoint; Chemotherapy; Surgery; Randomized controlled trial; Progressive disease; Pathology; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02318447,0.004709827,0.00720509,0.001181216,0.002916413,0.002987109,0.00407007,0.007381915,0.04188095],"category_scores_gemma":[0.01680249,0.00264982,0.004373987,0.00162454,0.003328834,0.003283303,0.001857227,0.007570481,0.01097126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003037665,"about_ca_system_score_gemma":0.009997205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510287,"about_ca_topic_score_gemma":0.004188674,"domain_scores_codex":[0.9902192,0.006124001,0.0008266535,0.001002039,0.0006882981,0.001139791],"domain_scores_gemma":[0.9919291,0.001431665,0.001741262,0.001150421,0.001340344,0.002407266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9484,0.01512829,0.0006003181,0.005794766,0.0005474702,0.0002869641,0.0003519261,0.000931292,0.003580669,0.001289006,0.009120716,0.01396877],"study_design_scores_gemma":[0.9315497,0.04908547,0.001492796,0.0007174226,0.0002843387,0.00008033676,0.00007463207,0.0005830447,0.0004867059,0.0008015287,0.01479191,0.00005206845],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01087985,0.0005059214,0.001531209,0.000443529,0.0004171184,0.9828832,0.001567294,0.0001240385,0.001647855],"genre_scores_gemma":[0.012445,0.0004048732,0.002730764,0.0006204832,0.0001390408,0.9817814,0.0006116612,0.00001600589,0.001250906],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04188095,"threshold_uncertainty_score":0.1401058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1179081311383106,"score_gpt":0.4938336340869315,"score_spread":0.375925502948621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}