{"id":"W4388968728","doi":"10.1016/j.antiviral.2023.105758","title":"A phenothiazine urea derivative broadly inhibits coronavirus replication via viral protease inhibition","year":2023,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Saint Vincent University; Saint Mary's University; University of Saskatchewan; Dalhousie University","funders":"","keywords":"Proteases; Protease; Polyproteins; Viral replication; Biology; Coronavirus; Biochemistry; Virology; Enzyme; Virus; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294983,0.0003436792,0.0002154443,0.0001246693,0.000118571,0.0001350349,0.0002416375,0.0002274368,0.001171928],"category_scores_gemma":[0.00008771378,0.0001153183,0.0001674516,0.0001056683,0.0001706868,0.0001335203,0.000121807,0.0004250869,0.0001910668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000212028,"about_ca_system_score_gemma":0.000184934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664637,"about_ca_topic_score_gemma":0.001583377,"domain_scores_codex":[0.9999237,0.00001425441,0.000004655789,0.00001114246,0.0000162463,0.00003002744],"domain_scores_gemma":[0.9999645,0.000007223284,0.000009556346,0.000004043306,0.000004599954,0.00001008341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002048838,0.00003996438,0.00007359195,0.00003642572,0.000006399137,0.00003257762,0.000008034358,0.0001048248,0.9973708,0.00005330045,0.00008461879,0.001984612],"study_design_scores_gemma":[0.0001263843,0.002373802,0.002446793,0.000004926628,0.0000198943,0.0002586725,0.00001358417,0.0009033526,0.9920873,0.00003035611,0.001729877,0.000005026658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932646,0.001969561,0.001838099,0.0001188809,0.0000506418,0.00007044467,0.0001806325,0.0001102184,0.002396952],"genre_scores_gemma":[0.9961041,0.0009626024,0.001204957,0.00005331017,0.00001287236,0.00002512648,0.0002061656,0.000006398658,0.001424443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171928,"threshold_uncertainty_score":0.003920436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1437504809844165,"score_gpt":0.4499879883160517,"score_spread":0.3062375073316352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}