{"id":"W4388968728","doi":"10.1016/j.antiviral.2023.105758","title":"A phenothiazine urea derivative broadly inhibits coronavirus replication via viral protease inhibition","year":2023,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Saint Vincent University; Saint Mary's University; University of Saskatchewan; Dalhousie University","funders":"","keywords":"Proteases; Protease; Polyproteins; Viral replication; Biology; Coronavirus; Biochemistry; Virology; Enzyme; Virus; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003148118,0.0002693376,0.0003882848,0.000996571,0.0004299717,0.0001197676,0.0002577404,0.0002508905,0.00001886007],"category_scores_gemma":[0.002497605,0.0002427604,0.0001517303,0.003274066,0.0005479734,0.0004324852,0.0004384019,0.001257908,0.004283199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573559,"about_ca_system_score_gemma":0.0006938579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008621418,"about_ca_topic_score_gemma":0.00004758082,"domain_scores_codex":[0.9947374,0.0004686458,0.0004683509,0.001011597,0.002129612,0.001184373],"domain_scores_gemma":[0.9973544,0.0003799406,0.00008722756,0.001062805,0.001026181,0.00008941696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298127,0.000328104,0.01397386,0.0001960142,0.00004836735,0.0003457489,0.0005563609,8.909992e-8,0.9266452,0.0006405798,0.004123504,0.05184401],"study_design_scores_gemma":[0.002254148,0.001136438,0.0353662,0.000248686,0.00001609901,0.00003641937,0.0002187796,0.001658865,0.937669,0.003088727,0.01804568,0.000260919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841459,0.0001329406,0.0002630217,0.002253097,0.00005511964,0.002432184,0.00002645848,0.0003730977,0.01031814],"genre_scores_gemma":[0.9929799,0.00002391611,0.000119921,0.004511382,0.0004064241,0.0006802805,0.0001112153,0.00007816926,0.001088823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05158309,"threshold_uncertainty_score":0.9964921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1437504809844165,"score_gpt":0.4499879883160517,"score_spread":0.3062375073316352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}