{"id":"W4388968927","doi":"10.1186/s12974-023-02962-z","title":"14-3-3 $$\\upzeta /\\updelta$$-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging","keywords":"Astrogliosis; Neurodegeneration; Microglia; Neuroscience; Gliosis; Medicine; Biomarker; Psychology; Disease; Inflammation; Pathology; Biology; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004490241,0.0002305854,0.0004086261,0.0007731841,0.00006865474,0.00006174873,0.0001545096,0.00009960846,0.000177445],"category_scores_gemma":[0.0005421988,0.0001960286,0.0002101602,0.0008251555,0.0000581955,0.0005453118,0.00005491721,0.0004530887,0.0003446178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001079934,"about_ca_system_score_gemma":0.0005246275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002495049,"about_ca_topic_score_gemma":0.0000031607,"domain_scores_codex":[0.9968371,0.0001615943,0.000973253,0.0002636884,0.001343613,0.0004207474],"domain_scores_gemma":[0.9978365,0.000125276,0.0005710339,0.0003203221,0.0003814053,0.0007655157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01472922,0.003135003,0.7517555,0.0003865776,0.02600127,0.05559533,0.001212435,0.0002101226,0.06971715,0.00005395174,0.05080954,0.02639384],"study_design_scores_gemma":[0.006955374,0.001329583,0.9777403,0.0004497832,0.002188387,0.0002454538,0.00008058827,0.003712222,0.005763709,0.0007135232,0.0005008058,0.0003202378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945183,0.001371418,0.000005428996,0.003196141,0.0001447963,0.0005080414,0.00007072969,0.00006175073,0.0001234102],"genre_scores_gemma":[0.9988067,0.0006686159,0.0000157938,0.00009507898,0.0001263659,0.00001335356,0.0001747612,0.00004365567,0.00005565491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2259848,"threshold_uncertainty_score":0.7993813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795330072381772,"score_gpt":0.3235936078641878,"score_spread":0.28564030714037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}