{"id":"W4388998622","doi":"10.1038/s41467-023-43605-4","title":"Modulation of insulin secretion by RBFOX2-mediated alternative splicing","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Anschutz Medical Campus, University of Colorado; Diabetes Research Connection","keywords":"Exocytosis; Insulin; Secretion; Alternative splicing; Glucose homeostasis; Cell biology; Biology; RNA splicing; Regulator; Endocrinology; Homeostasis; Internal medicine; RNA; Messenger RNA; Gene; Insulin resistance; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146836,0.0003169777,0.0001836838,0.0001548617,0.0001202352,0.0003532476,0.0002868686,0.0002647541,0.0007595735],"category_scores_gemma":[0.000147451,0.0001347321,0.0002714192,0.0001419909,0.0002521877,0.0001838691,0.0002803165,0.0004883103,0.0002018203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981814,"about_ca_system_score_gemma":0.0001047411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002486968,"about_ca_topic_score_gemma":0.0004013789,"domain_scores_codex":[0.9997836,0.00003299049,0.00001792191,0.00006622676,0.00006015362,0.00003915503],"domain_scores_gemma":[0.9998864,0.0000179135,0.00004041458,0.00001650751,0.00001190959,0.00002681386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000070753,0.000008807129,0.0002024222,0.00001162834,0.000003726123,0.0000476059,0.000007834598,0.00003399989,0.9985695,0.00013578,0.00002262828,0.0008853945],"study_design_scores_gemma":[0.00003775707,0.0001645129,0.005369285,0.000005473641,0.00002232686,0.0004692295,0.00002639722,0.002552028,0.9882364,0.0001165634,0.002990397,0.000009595012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818107,0.001373145,0.01396512,0.0001614588,0.0000669174,0.00003199874,0.0003429965,0.0001709925,0.00207661],"genre_scores_gemma":[0.9936001,0.0006007466,0.00395064,0.00008547024,0.00002051456,0.00002326513,0.0003722611,0.00005052588,0.001296569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007595735,"threshold_uncertainty_score":0.002541006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02624548089880765,"score_gpt":0.3161800203310011,"score_spread":0.2899345394321935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}