{"id":"W4389010638","doi":"10.1096/fasebj.30.1_supplement.941.11","title":"Natriuretic Peptide Receptor‐C Agonist Attenuates the Enhanced Expression of Gqα, PLCβ1 Proteins and Vascular Smooth Muscle Cell Hypertrophy From Spontaneously Hypertensive Rats: Role of ROS and ROS‐Mediated Signalling","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Vascular smooth muscle; Internal medicine; P22phox; Atrial natriuretic peptide; Endocrinology; NADPH oxidase; Muscle hypertrophy; NOX4; Agonist; Gq alpha subunit; Receptor; G protein; Chemistry; Natriuretic peptide; Brain natriuretic peptide; Biology; Medicine; Oxidative stress","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179104,0.0008555121,0.0007123476,0.0004199372,0.0002033663,0.0002087075,0.0002053135,0.000400171,0.001917983],"category_scores_gemma":[0.0001332613,0.0003333941,0.0004514819,0.0001849702,0.0003172822,0.0003054363,0.0002773233,0.001228193,0.0002988874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207723,"about_ca_system_score_gemma":0.0003208282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156253,"about_ca_topic_score_gemma":0.001614673,"domain_scores_codex":[0.9998629,0.00002034035,0.0000142941,0.00001850008,0.00003134085,0.00005252791],"domain_scores_gemma":[0.9997517,0.00001424311,0.00007978015,0.00001950915,0.00002258737,0.0001121468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007760433,0.0001149717,0.0001791097,0.00005330179,0.000009795041,0.0000677778,0.00002154931,0.0000252332,0.9976661,0.00001935955,0.00003303164,0.001033782],"study_design_scores_gemma":[0.0002123468,0.004925362,0.03362125,0.00002404269,0.0001156013,0.0003742887,0.0001638978,0.001087869,0.9576243,0.0001074045,0.00172205,0.00002156002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975069,0.001041069,0.0006251814,0.0001376571,0.00003863088,0.00001825229,0.0001647357,0.00006044959,0.0004071456],"genre_scores_gemma":[0.9921129,0.002063359,0.001266456,0.0001616907,0.00005179403,0.00008922465,0.0005494736,0.00002294378,0.003682174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001917983,"threshold_uncertainty_score":0.006416321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007180418021899707,"score_gpt":0.1939020932047216,"score_spread":0.1867216751828219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}