{"id":"W4389020211","doi":"10.1096/fasebj.31.1_supplement.778.3","title":"Leigh Syndrome French Canadian Type Patient Fibroblasts Exhibit Energy Metabolism Adaptations Through a Warburg‐like Effect","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Glycolysis; mTORC1; Oxidative phosphorylation; Mitochondrion; Warburg effect; Protein kinase B; Citric acid cycle; Pyruvate dehydrogenase complex; Biology; Pyruvate decarboxylation; PI3K/AKT/mTOR pathway; Cytochrome c oxidase; Cell biology; Chemistry; Phosphorylation; Biochemistry; Metabolism; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298226,0.0008269146,0.0002546624,0.0007190137,0.0006399201,0.0003282627,0.0002709528,0.0004689369,0.006287438],"category_scores_gemma":[0.0002962934,0.0001501702,0.0003433538,0.0004741699,0.0004219019,0.0001325602,0.0001933206,0.0004277425,0.0005295007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001172918,"about_ca_system_score_gemma":0.0005301847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05368317,"about_ca_topic_score_gemma":0.04457207,"domain_scores_codex":[0.9998449,0.00001360427,0.000008377643,0.00004150472,0.0000583965,0.00003315457],"domain_scores_gemma":[0.9998455,0.0000427389,0.00004566415,0.00001178402,0.00002614793,0.00002821624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001271356,0.0001235215,0.02633493,0.0001770367,0.0001144132,0.08255991,0.0006566816,0.0006244865,0.862025,0.001712674,0.002888642,0.0215114],"study_design_scores_gemma":[0.0002342689,0.0007125524,0.357202,0.00007321895,0.000305361,0.2499757,0.00111474,0.00386241,0.3527571,0.0008504229,0.03279459,0.000117716],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912548,0.001135709,0.001467452,0.000417914,0.00005421328,0.00003850568,0.001064707,0.0001847899,0.004381829],"genre_scores_gemma":[0.9946846,0.000438141,0.001015889,0.0001063134,0.00001929965,0.00002155569,0.000379065,0.0000294054,0.003305799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05368317,"threshold_uncertainty_score":0.1067414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253343685538338,"score_gpt":0.2312394437125123,"score_spread":0.2187060068571289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}