{"id":"W4389022239","doi":"10.1096/fasebj.31.1_supplement.990.7","title":"When the Tail Wags the Dog: Phosphodiesterase 4D7 Regulation of a cAMP‐signalosome Located at the Rear of Migrating Smooth Muscle Cells Regulates Localized RhoA/ROCK Signaling and Tail Retraction During Migration","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Phosphodiesterase; Gene isoform; Cell biology; RHOA; Vascular smooth muscle; Cyclic adenosine monophosphate; Intracellular; Biology; Phosphodiesterase 3; Chemistry; Internal medicine; Signal transduction; Endocrinology; Biochemistry; Gene; Enzyme; Smooth muscle; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856283,0.0002613019,0.0003265983,0.0002620666,0.0005208935,0.0006409749,0.000305934,0.0006518622,0.005673864],"category_scores_gemma":[0.0001841073,0.0002690509,0.0005245704,0.0001222236,0.0005698297,0.0006457391,0.0004815572,0.001524542,0.001766332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006312525,"about_ca_system_score_gemma":0.0003870731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137255,"about_ca_topic_score_gemma":0.001889734,"domain_scores_codex":[0.9997416,0.00002635977,0.00001571842,0.00006069402,0.00006115255,0.00009442191],"domain_scores_gemma":[0.9997986,0.00001192125,0.00004069114,0.00001595623,0.00002753904,0.0001053341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002268663,0.00001968302,0.0003002866,0.00004921844,0.0000065597,0.0001350107,0.00002967792,0.00003185783,0.9972914,0.000342489,0.0003218258,0.001245162],"study_design_scores_gemma":[0.00004620858,0.0001898286,0.01233969,0.00002409132,0.00002447888,0.0002853925,0.0002007554,0.001443118,0.9772754,0.0002146675,0.007944996,0.00001136275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798335,0.003172053,0.007444184,0.001738263,0.0006368893,0.00005780526,0.000521247,0.0003432272,0.006252854],"genre_scores_gemma":[0.9822934,0.0009434341,0.001976045,0.0006165107,0.00005100743,0.00004416948,0.0004167681,0.0000955453,0.01356309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005673864,"threshold_uncertainty_score":0.01898092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085104965463973,"score_gpt":0.2237787061694648,"score_spread":0.2129276565148251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}