{"id":"W4389023590","doi":"10.1096/fasebj.30.1_supplement.833.10","title":"Structural And Functional Analysis Of Acetylcholinesterase Complexes With “In Situ Click‐Chemistry” Inhibitors","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pacific Institute for Climate Solutions","keywords":"Chemistry; Active site; Cycloaddition; Click chemistry; Stereochemistry; Acetylcholinesterase; Ligand (biochemistry); Alkyne; Triazole; Azide; Binding site; Enzyme; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467577,0.0004142285,0.0002067299,0.0001373172,0.0001513313,0.0002772604,0.0004988696,0.0003027643,0.001153251],"category_scores_gemma":[0.0001426387,0.0001756427,0.0002864818,0.0001795634,0.0002436946,0.0001942617,0.0001014757,0.0004447098,0.0001989929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005107906,"about_ca_system_score_gemma":0.0001011896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001887565,"about_ca_topic_score_gemma":0.001217588,"domain_scores_codex":[0.9998502,0.00001544644,0.000008244264,0.00002732632,0.00007228857,0.00002664956],"domain_scores_gemma":[0.9999206,0.00001741513,0.00002257691,0.000007397132,0.00001476676,0.0000172689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009870022,0.00003933148,0.0001484316,0.00002021322,0.00001413366,0.00004940349,0.00001943532,0.0003726077,0.998715,0.00009939137,0.00003866915,0.0003846045],"study_design_scores_gemma":[0.00001394746,0.0002203457,0.002678738,0.000001930057,0.00002099296,0.0001600067,0.00002110558,0.003735329,0.9924913,0.00001502894,0.0006356878,0.000005648293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977663,0.0002759519,0.001087208,0.00002245067,0.000005846606,0.000006193873,0.0001253982,0.00002556768,0.0006850649],"genre_scores_gemma":[0.9969813,0.0002599212,0.001013191,0.00001893038,0.000004885874,0.000009459255,0.0005119217,0.00001632209,0.001184084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887565,"threshold_uncertainty_score":0.00385803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02493020047755073,"score_gpt":0.2706912543778847,"score_spread":0.2457610539003339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}