{"id":"W4389029020","doi":"10.1093/ofid/ofad500.2471","title":"2888. Safety and Immunogenicity of an Adjuvanted Chikungunya Virus (CHIKV) Virus-like Particle (VLP) Based Vaccine in Two Pivotal Phase 3 Trials, ≥12 Years of Age","year":2023,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada)","funders":"","keywords":"Medicine; Placebo; Immunogenicity; Adverse effect; Titer; Internal medicine; Vaccination; Randomization; Immunology; Clinical trial; Virus; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007208686,0.0002889351,0.001271912,0.0002014036,0.0001087315,0.00006246302,0.0002610344,0.000071752,0.0005151705],"category_scores_gemma":[0.0007381064,0.0002713189,0.000348932,0.0006536975,0.0001061596,0.0003111646,0.0002392023,0.0001475357,0.00001491038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006315303,"about_ca_system_score_gemma":0.0002688317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004655759,"about_ca_topic_score_gemma":0.003902158,"domain_scores_codex":[0.9972186,0.0003813315,0.001066502,0.0004981494,0.000340116,0.0004953126],"domain_scores_gemma":[0.9981024,0.0003282957,0.0003986114,0.000670684,0.00009540705,0.0004046592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07387728,0.01663654,0.5752692,0.0005387202,0.001299277,0.0009386419,0.0004012747,0.0008411171,0.1898816,0.0007833298,0.001185315,0.1383477],"study_design_scores_gemma":[0.08012791,0.003182022,0.8874398,0.0003326168,0.001360226,0.000017072,0.0003375228,0.01580301,0.009378472,0.0004554916,0.00107096,0.0004948296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947447,0.00118703,0.00003435321,0.0001327116,0.0001554472,0.001818313,0.001498084,0.0001079417,0.0003213914],"genre_scores_gemma":[0.9985092,0.0002596485,0.0000175367,0.0003813826,0.00005800793,0.0001224225,0.0005185038,0.0000524393,0.00008091186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3121707,"threshold_uncertainty_score":0.9999739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061836157436805,"score_gpt":0.3483154360971528,"score_spread":0.3276970745227848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}