{"id":"W4389029020","doi":"10.1093/ofid/ofad500.2471","title":"2888. Safety and Immunogenicity of an Adjuvanted Chikungunya Virus (CHIKV) Virus-like Particle (VLP) Based Vaccine in Two Pivotal Phase 3 Trials, ≥12 Years of Age","year":2023,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada)","funders":"","keywords":"Medicine; Placebo; Immunogenicity; Adverse effect; Titer; Internal medicine; Vaccination; Randomization; Immunology; Clinical trial; Virus; Antibody; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00405516,0.0007008367,0.001032507,0.0001662181,0.000314671,0.0006035486,0.0004300474,0.001017012,0.004564833],"category_scores_gemma":[0.002225033,0.000341113,0.0009994817,0.000212931,0.00041299,0.0005421214,0.0002244652,0.001392473,0.0006740938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454224,"about_ca_system_score_gemma":0.001128125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634986,"about_ca_topic_score_gemma":0.00141959,"domain_scores_codex":[0.9988998,0.0006635567,0.0001136702,0.0001391802,0.00009896356,0.00008480503],"domain_scores_gemma":[0.9985623,0.0003777054,0.0004010457,0.00009207759,0.0002710276,0.0002958752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8762962,0.01124666,0.008286648,0.002469871,0.00161786,0.000115389,0.0001997622,0.0005664392,0.03283602,0.0002254844,0.003410891,0.06272885],"study_design_scores_gemma":[0.6031252,0.3669019,0.01815691,0.0002169767,0.001358998,0.0001888834,0.00005477018,0.0005793925,0.004658776,0.0002140955,0.00452167,0.00002241556],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782244,0.008254874,0.001392096,0.0006041249,0.0003153356,0.005775086,0.002401015,0.00007768492,0.002955434],"genre_scores_gemma":[0.9836097,0.00257301,0.002692836,0.0007219547,0.0002344801,0.005611152,0.001853234,0.00002281996,0.002680763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004564833,"threshold_uncertainty_score":0.02144599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061836157436805,"score_gpt":0.3483154360971528,"score_spread":0.3276970745227848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}