{"id":"W4389029085","doi":"10.1093/ofid/ofad500.2476","title":"2893 A. Efficacy and Safety of Aztreonam-Avibactam for the Treatment of Serious Infections Due to Gram-Negative Bacteria, Including Metallo-β-Lactamase-Producing Pathogens: Phase 3 REVISIT Study","year":2023,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada)","funders":"Pfizer","keywords":"Medicine; Aztreonam; Ceftazidime/avibactam; Colistin; Internal medicine; Clinical endpoint; Pneumonia; Adverse effect; Avibactam; Randomized controlled trial; Antibiotics; Microbiology; Pseudomonas aeruginosa; Bacteria; Antibiotic resistance; Biology; Imipenem","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002587161,0.001007869,0.001678817,0.0002557859,0.0003210026,0.0009523437,0.0006841443,0.001206476,0.006425159],"category_scores_gemma":[0.002025047,0.0004449569,0.001735233,0.0002120098,0.000690525,0.000651254,0.0003002655,0.001965233,0.0009839039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004931631,"about_ca_system_score_gemma":0.001262829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005830542,"about_ca_topic_score_gemma":0.001214761,"domain_scores_codex":[0.998976,0.0006000592,0.00007551143,0.0001232345,0.0001063237,0.0001189192],"domain_scores_gemma":[0.9986041,0.0003993062,0.0003493444,0.0001363673,0.0001556449,0.0003552845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9175394,0.0207342,0.002031148,0.0006338076,0.0009357432,0.00004798764,0.00008089389,0.0005517803,0.01902499,0.0001297499,0.00133217,0.03695815],"study_design_scores_gemma":[0.5588834,0.4282671,0.006017401,0.0000539005,0.0008239077,0.00006188062,0.0000288293,0.0006391383,0.00340549,0.0001153619,0.001678804,0.00002467375],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887592,0.00279975,0.0006429227,0.0003210822,0.0001824455,0.003870136,0.001522635,0.0000759474,0.001825848],"genre_scores_gemma":[0.9892915,0.001591924,0.001538084,0.000643532,0.0003167127,0.00264251,0.001544892,0.0000292309,0.00240154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006425159,"threshold_uncertainty_score":0.02149433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02350754749063302,"score_gpt":0.3335807638619493,"score_spread":0.3100732163713162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}