{"id":"W4389032288","doi":"10.1101/2023.11.25.568631","title":"Origin of evolutionary bifurcation in an enzyme","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Canada's Michael Smith Genome Sciences Centre","funders":"European Commission; Natural Sciences and Engineering Research Council of Canada; Australian Synchrotron; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Australian Government","keywords":"Epistasis; Evolutionary biology; Biology; Most recent common ancestor; Phenotype; Genetics; Evolutionary dynamics; Mutation; Gene; Phylogenetics; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003448281,0.0002262326,0.0004594603,0.0004777042,0.0005851703,0.001039451,0.0003619898,0.0008940711,0.001694344],"category_scores_gemma":[0.0009863535,0.0003074322,0.0003834822,0.0002454308,0.0009539747,0.001060424,0.001078884,0.00105671,0.0006137184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001415325,"about_ca_system_score_gemma":0.0004069263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003794627,"about_ca_topic_score_gemma":0.0002153934,"domain_scores_codex":[0.9997326,0.00004141806,0.00002146189,0.00008407005,0.00007568596,0.00004476626],"domain_scores_gemma":[0.9997539,0.00005323844,0.00003942143,0.00005898125,0.00003856629,0.0000558057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000256855,0.0001095392,0.01005257,0.000248562,0.00009733411,0.001954158,0.0005215407,0.03655101,0.7258549,0.1956333,0.000983605,0.0277366],"study_design_scores_gemma":[0.0000989914,0.0005275475,0.01624724,0.00009774636,0.00007893751,0.003152742,0.0003860739,0.3575484,0.3406057,0.2555033,0.02555123,0.0002021199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9163105,0.0009104615,0.06641622,0.0009167478,0.00009608951,0.00005463519,0.0001363291,0.0005158285,0.01464308],"genre_scores_gemma":[0.9881219,0.0001804861,0.009882198,0.00006782348,0.00001036922,0.00002705856,0.00009318243,0.00004190256,0.001575297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694344,"threshold_uncertainty_score":0.01026899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763677603249189,"score_gpt":0.2531198755288144,"score_spread":0.2354830994963225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}