{"id":"W4389034252","doi":"10.1096/fasebj.30.1_supplement.1268.3","title":"THE DUAL ACTIONS OF DNA REPAIR ENZYME, PARP‐1, IN COLON INFLAMMATION AND CARCINOGENESIS","year":2016,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canadian Bureau for International Education","keywords":"Carcinogenesis; Cancer research; Genome instability; Colorectal cancer; DNA repair; Poly ADP ribose polymerase; Mouse model of colorectal and intestinal cancer; Inflammation; Adenomatous polyposis coli; Biology; DNA damage; Cancer; Immunology; Polymerase; Genetics; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007641959,0.0004867922,0.0004271641,0.0004101146,0.0003452889,0.00102369,0.0004545992,0.0009133209,0.002448112],"category_scores_gemma":[0.0007110738,0.0003463314,0.0007909344,0.0006464192,0.0006581512,0.0009760713,0.0006543064,0.002570418,0.001036027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004921014,"about_ca_system_score_gemma":0.0004168659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002878052,"about_ca_topic_score_gemma":0.0003556022,"domain_scores_codex":[0.9994428,0.0001330157,0.00005717823,0.0001499494,0.0001332664,0.00008373096],"domain_scores_gemma":[0.9995611,0.0001227405,0.0001459584,0.00004142115,0.00005864644,0.00007009682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002468759,0.0009050205,0.007873895,0.003367112,0.0003050414,0.0008734316,0.0003173204,0.001357442,0.7453412,0.01081933,0.006708719,0.2196627],"study_design_scores_gemma":[0.0003658389,0.009314161,0.02230321,0.0007604207,0.0005023769,0.005454075,0.0004506049,0.002057191,0.8072664,0.008101264,0.1432753,0.000149332],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3574293,0.5487813,0.04418848,0.02459619,0.004180306,0.0004151191,0.001102546,0.0003565683,0.01895017],"genre_scores_gemma":[0.7036463,0.2488067,0.02561477,0.003627091,0.0009843307,0.0003014065,0.000661605,0.00003489036,0.01632285],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002448112,"threshold_uncertainty_score":0.008189738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03208335108758823,"score_gpt":0.2939019990604868,"score_spread":0.2618186479728985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}