{"id":"W4389039268","doi":"10.1139/bcb-2023-0211","title":"Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a), a mark of super-enhancers","year":2023,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Lethbridge; Research Institute in Oncology and Hematology; University of Manitoba","funders":"CancerCare Manitoba Foundation","keywords":"Biology; Enhancer; Chromatin; Genetics; Locus control region; Histone; Histone H4; Histone code; Nucleosome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908185,0.000215554,0.0002608177,0.00008907526,0.00007792395,0.000005068391,0.0001593562,0.0005396892,0.00008673241],"category_scores_gemma":[0.00009691025,0.0002155291,0.0001087237,0.0004244017,0.0002740853,0.00000230559,0.0002175531,0.0001061431,0.00002284846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005334143,"about_ca_system_score_gemma":0.00008689996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002688139,"about_ca_topic_score_gemma":0.000005009826,"domain_scores_codex":[0.998651,0.00005347614,0.0003271585,0.0005505548,0.00008865286,0.0003291698],"domain_scores_gemma":[0.9992323,0.00004153469,0.0001541034,0.0003674284,0.00008818378,0.0001164811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002375611,0.00003552859,0.001020319,0.00007218278,0.00006137307,0.000001919073,0.00001705026,0.00004626295,0.9884865,0.000006246439,0.005244408,0.004770605],"study_design_scores_gemma":[0.0007342829,0.0002474702,0.0009566974,0.000009671811,0.00003203983,0.00001110008,0.0000265306,0.0001547417,0.9539644,0.00002646794,0.0436029,0.0002336895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909108,0.005789462,0.00008843269,0.0001539857,0.000203099,0.0001290123,0.00006817051,0.00003850901,0.002618566],"genre_scores_gemma":[0.9883114,0.002105823,0.0001691711,0.00005173157,0.0001833092,0.00002062311,0.001191431,0.00002417678,0.007942371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03835849,"threshold_uncertainty_score":0.8789021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006213028677424546,"score_gpt":0.2427915004890683,"score_spread":0.2365784718116438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}