{"id":"W4389039268","doi":"10.1139/bcb-2023-0211","title":"Histone H4 asymmetrically dimethylated at arginine 3 (H4R3me2a), a mark of super-enhancers","year":2023,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; University of Lethbridge; Research Institute in Oncology and Hematology; University of Manitoba","funders":"CancerCare Manitoba Foundation","keywords":"Biology; Enhancer; Chromatin; Genetics; Locus control region; Histone; Histone H4; Histone code; Nucleosome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001393597,0.0002678102,0.0002380945,0.0004634623,0.0003185163,0.0002490442,0.0002483712,0.0001952058,0.002342687],"category_scores_gemma":[0.000156647,0.0001864793,0.0004483968,0.000399678,0.000206629,0.0001760814,0.0002106271,0.0002956376,0.001009332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191348,"about_ca_system_score_gemma":0.0002263841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003081897,"about_ca_topic_score_gemma":0.00619044,"domain_scores_codex":[0.9998173,0.00001281968,0.000006924002,0.00006422648,0.00006294729,0.00003580078],"domain_scores_gemma":[0.9998719,0.00002131389,0.00003417115,0.0000165268,0.00002795071,0.00002821602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205367,0.00000946049,0.006364729,0.0000654344,0.00003317696,0.0001039421,0.00004988218,0.00009507346,0.9888436,0.0001495209,0.0001538592,0.004010786],"study_design_scores_gemma":[0.00001656884,0.0001336913,0.1982187,0.00001559303,0.00009181743,0.0008952611,0.0001247542,0.001497413,0.7806132,0.0004156856,0.01795575,0.00002158624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745608,0.004106415,0.01363443,0.00009226136,0.00003582242,0.00002375237,0.003316032,0.0002536564,0.003976936],"genre_scores_gemma":[0.9749542,0.001225374,0.007911751,0.00009609121,0.00002004063,0.00002435505,0.008942928,0.00006704973,0.00675839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003081897,"threshold_uncertainty_score":0.007837117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006213028677424546,"score_gpt":0.2427915004890683,"score_spread":0.2365784718116438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}