{"id":"W4389047718","doi":"10.1038/s41375-023-02093-7","title":"Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Daiichi Sankyo Europe; Moonshot Research and Development Program; Kobayashi Foundation for Cancer Research; Daiichi Sankyo Foundation of Life Science; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; SGH Foundation; SENSHIN Medical Research Foundation; University of Tsukuba; Yasuda Memorial Medical Foundation; Japan Agency for Medical Research and Development","keywords":"Biology; Immune system; CD8; Phenotype; Tumor microenvironment; Follicular lymphoma; T cell; Single-cell analysis; Cell; Immunology; Cancer research; Lymphoma; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219746,0.00008460547,0.0001467016,0.0002886249,0.0001063199,0.000334358,0.00007570402,0.0001634402,0.0006941321],"category_scores_gemma":[0.000138002,0.00007811833,0.00008391454,0.0001629928,0.0001427925,0.0001350736,0.0001459371,0.0001509407,0.0001332832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001178837,"about_ca_system_score_gemma":0.00005424481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003922492,"about_ca_topic_score_gemma":0.0005403957,"domain_scores_codex":[0.9999228,0.000008945114,0.000004395448,0.00003166779,0.00001573323,0.00001651986],"domain_scores_gemma":[0.9999352,0.00002474338,0.00001345869,0.000006906568,0.000009617137,0.00001006342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006808632,0.000008615569,0.008106978,0.00002638409,0.000007318733,0.00008443141,0.00007504044,0.0004535196,0.9883308,0.00006567534,0.0000287466,0.002744443],"study_design_scores_gemma":[0.00002155426,0.0003012363,0.2295526,0.00001391779,0.00007933948,0.001528454,0.0007075215,0.03610957,0.7277589,0.0008868246,0.003021585,0.00001858309],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956116,0.0001727064,0.003649568,0.00001198482,0.000001973897,0.000006981735,0.0002092344,0.00004168764,0.0002942532],"genre_scores_gemma":[0.9981755,0.00004697524,0.001478979,0.000007487107,0.000002561912,0.000006393487,0.0001423379,0.000005196212,0.0001346375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006941321,"threshold_uncertainty_score":0.002322078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658978641655458,"score_gpt":0.235408483842232,"score_spread":0.2188186974256774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}