{"id":"W4389068705","doi":"10.14814/phy2.15852","title":"Influence of metabolic stress and metformin on synaptic protein profile in SH‐SY5Y‐derived neurons","year":2023,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University; Alzheimer's Society","keywords":"AMPK; Metformin; NeuN; SH-SY5Y; Neurite; Synaptophysin; Neurodegeneration; Activator (genetics); PI3K/AKT/mTOR pathway; Endocrinology; Protein kinase B; Insulin; Chemistry; Internal medicine; AMP-activated protein kinase; Biology; Signal transduction; Cell biology; Medicine; Protein kinase A; Kinase; Biochemistry; Neuroblastoma; Receptor; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383662,0.0002550585,0.0004056095,0.0001775823,0.0002005445,0.0002822999,0.0002235738,0.000275621,0.001125516],"category_scores_gemma":[0.000100824,0.0001113955,0.0003668215,0.0001812825,0.0001502646,0.0002478553,0.0001685277,0.0006303747,0.0002475213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002601103,"about_ca_system_score_gemma":0.0003238787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001601779,"about_ca_topic_score_gemma":0.00315093,"domain_scores_codex":[0.9998858,0.00001326023,0.00002117657,0.00002003054,0.00002144924,0.00003817622],"domain_scores_gemma":[0.9999331,0.000010011,0.00001540618,0.000007151881,0.00001196856,0.00002241872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002787906,0.0004032289,0.0008476223,0.0001352259,0.00003463923,0.0002237033,0.00007172659,0.000172163,0.9916328,0.000100523,0.0002170552,0.003373427],"study_design_scores_gemma":[0.0001630017,0.00395553,0.03079071,0.00003123073,0.00009254542,0.0002041953,0.0003084794,0.001622456,0.9602238,0.00009204794,0.002497857,0.00001820394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974546,0.0009007378,0.0001608836,0.00007554793,0.00005281777,0.0000152104,0.0004839549,0.00001192581,0.0008443713],"genre_scores_gemma":[0.9950524,0.001424156,0.0005837809,0.00009011126,0.00001638788,0.00007148484,0.0007866115,0.000008525377,0.001966581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001601779,"threshold_uncertainty_score":0.003765225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588118707344505,"score_gpt":0.2629350577642579,"score_spread":0.2470538706908129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}