{"id":"W4389068705","doi":"10.14814/phy2.15852","title":"Influence of metabolic stress and metformin on synaptic protein profile in SH‐SY5Y‐derived neurons","year":2023,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Brock University; Alzheimer's Society","keywords":"AMPK; Metformin; NeuN; SH-SY5Y; Neurite; Synaptophysin; Neurodegeneration; Activator (genetics); PI3K/AKT/mTOR pathway; Endocrinology; Protein kinase B; Insulin; Chemistry; Internal medicine; AMP-activated protein kinase; Biology; Signal transduction; Cell biology; Medicine; Protein kinase A; Kinase; Biochemistry; Neuroblastoma; Receptor; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932828,0.000156465,0.0003138601,0.00005415824,0.0000326576,0.00000760293,0.0001002453,0.0001174898,0.00001989579],"category_scores_gemma":[0.0004809803,0.0001176437,0.00006438326,0.0001906557,0.0001323673,0.000005903937,0.0001416147,0.0001082142,0.000005338287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003160535,"about_ca_system_score_gemma":0.00003873579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002438902,"about_ca_topic_score_gemma":0.000005432095,"domain_scores_codex":[0.9987252,0.00008306605,0.0003282321,0.000450715,0.0001381677,0.0002746282],"domain_scores_gemma":[0.9993581,0.00001852436,0.0001665959,0.0003345926,0.00004744364,0.00007470017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004849699,0.00008773922,0.001259929,0.00005352077,0.00002894029,0.00005134106,0.00002462121,0.000784319,0.9905069,0.0002010722,0.00005615102,0.006896897],"study_design_scores_gemma":[0.0002714824,0.0003932243,0.2897847,0.00006595937,0.00001923985,0.000008645296,0.00004067057,0.00007283903,0.7033889,0.001215331,0.00449483,0.0002441934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915114,0.007908135,9.809669e-7,0.000009817387,0.00003938188,0.0003641358,0.00001675281,0.00001960444,0.0001297643],"genre_scores_gemma":[0.9954457,0.004064992,0.00004819974,0.0001091503,0.00005313797,0.0001692303,0.00004966749,0.00001204643,0.0000478913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2885248,"threshold_uncertainty_score":0.4797371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588118707344505,"score_gpt":0.2629350577642579,"score_spread":0.2470538706908129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}