{"id":"W4389069047","doi":"10.1111/apt.17816","title":"Efficacy and safety of upadacitinib for 16‐week extended induction and 52‐week maintenance therapy in patients with moderately to severely active ulcerative colitis","year":2023,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Eisai; Celltrion; AbbVie; Gilead Sciences; Mylan; GlaxoSmithKline; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Maintenance therapy; Ulcerative colitis; Clinical trial; Internal medicine; Population; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001800337,0.0003541968,0.001442057,0.0002264894,0.0002571655,0.0005548656,0.0003212806,0.0004929219,0.001308911],"category_scores_gemma":[0.001514347,0.0001978498,0.0009478014,0.0002972267,0.0003017008,0.0005156143,0.0002976334,0.001044285,0.0002443246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005880937,"about_ca_system_score_gemma":0.0005997885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002587405,"about_ca_topic_score_gemma":0.000707433,"domain_scores_codex":[0.999503,0.0001987311,0.00005716838,0.00006651333,0.00009599647,0.0000784884],"domain_scores_gemma":[0.9989126,0.0002907091,0.0004245594,0.00007997511,0.00005192119,0.0002403074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5201718,0.007883885,0.1324043,0.001226946,0.001742499,0.0005943627,0.0004424152,0.001704984,0.02353401,0.00008949135,0.001584746,0.3086205],"study_design_scores_gemma":[0.1028002,0.3709504,0.511624,0.0002690939,0.001679118,0.001874382,0.0001922226,0.002230365,0.004918238,0.0001286225,0.003265467,0.0000678389],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975246,0.001806975,0.00005752552,0.00007502256,0.0000116292,0.0001002767,0.00007301622,0.000009769313,0.0003412169],"genre_scores_gemma":[0.9989091,0.0004431626,0.0001439119,0.0000688959,0.00002591018,0.00008710935,0.0001745965,0.000001543446,0.0001456287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001800337,"threshold_uncertainty_score":0.009521246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275760131676594,"score_gpt":0.2905408983455519,"score_spread":0.2677832970287859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}