{"id":"W4389071712","doi":"","title":"Synthetic and External Controls in Clinical Trials – A Primer for Researchers","year":2020,"lang":"en","type":"article","venue":"SHILAP Revista de lepidopterología","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Primer (cosmetics); Clinical trial; Medicine; Psychology; Internal medicine; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007540399,0.0002231055,0.0008243676,0.00005770159,0.0000581616,0.00008192557,0.0003024899,0.0003199796,0.00003923499],"category_scores_gemma":[0.005651566,0.0002005607,0.0004234241,0.0001180479,0.0002245095,0.000005046793,0.0001535119,0.000258082,0.00001254236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002140115,"about_ca_system_score_gemma":0.0001094242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000880123,"about_ca_topic_score_gemma":0.00002185318,"domain_scores_codex":[0.995832,0.00179964,0.0009926141,0.0007280399,0.0001495767,0.0004981292],"domain_scores_gemma":[0.9983955,0.0004726195,0.0002730482,0.0004420353,0.0000736141,0.0003431753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00767492,0.0003100404,0.4714785,0.0003883084,0.001334111,0.00003644017,0.0002843302,0.0006878737,0.3875751,0.0007329345,0.0141726,0.1153249],"study_design_scores_gemma":[0.01025499,0.002414281,0.04212319,0.0001634309,0.0007313348,0.00003826713,0.00008091059,0.005524895,0.006588906,0.0007670489,0.9302742,0.001038512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712369,0.00749338,0.01591219,0.004296562,0.00005093782,0.0008511997,0.00002088304,0.00001620111,0.0001217182],"genre_scores_gemma":[0.9920228,0.0006695508,0.003495877,0.002727911,0.0007463353,0.0001030825,0.00003820626,0.00003489337,0.000161411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9161016,"threshold_uncertainty_score":0.8178626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347420558095873,"score_gpt":0.4056129574685086,"score_spread":0.2708709016589214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}