{"id":"W4389077974","doi":"10.1038/s41531-023-00601-1","title":"USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice","year":2023,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Parkinson Canada; Canadian Institutes of Health Research; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; Government of Canada; U.S. Department of Defense","keywords":"Deubiquitinating enzyme; Ubiquitin; Chemistry; Lewy body; Cell biology; Internal medicine; Biochemistry; Medicine; Biology; Parkinson's disease; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000294106,0.0002795371,0.0003832879,0.0006156234,0.0001009363,0.00003762398,0.00007135561,0.0001237127,0.00006060925],"category_scores_gemma":[0.0003204404,0.0002796277,0.000106621,0.0008296292,0.00007597299,0.0003939557,0.00008011323,0.0001173253,0.00003996255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001685918,"about_ca_system_score_gemma":0.0001463765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001283195,"about_ca_topic_score_gemma":0.00003640734,"domain_scores_codex":[0.9980364,0.0001145087,0.0004730016,0.0005521537,0.0004637509,0.0003601367],"domain_scores_gemma":[0.9987687,0.000131196,0.0002686049,0.0002876055,0.0001658867,0.0003780271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005754274,0.002686216,0.7772407,0.001852788,0.0002874452,0.0008839189,0.001314137,0.0003223917,0.1222308,0.0032483,0.0008283422,0.0833507],"study_design_scores_gemma":[0.00359431,0.0001777706,0.926561,0.0005748165,0.0002108351,0.000006988349,0.000203798,0.009330382,0.05382909,0.001807281,0.003452599,0.0002511343],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997097,0.0009605878,0.00002630904,0.0005453357,0.0000889839,0.0007908177,0.0001001764,0.0001659209,0.0002248703],"genre_scores_gemma":[0.9981269,0.0003984221,0.0001952982,0.0001773428,0.00006276643,0.0001179361,0.0006296475,0.0000496482,0.0002420549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493203,"threshold_uncertainty_score":0.9999656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0388630491586266,"score_gpt":0.3121029371020905,"score_spread":0.2732398879434639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}