{"id":"W4389083087","doi":"10.4049/immunohorizons.2300094","title":"PD-1 Impairs CD8+ T Cell Granzyme B Production in Aged Mice during Acute Viral Respiratory Infection","year":2023,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of General Medical Sciences; National Institutes of Health; Hillman Foundation; National Heart, Lung, and Blood Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse; Achievement Rewards for College Scientists Foundation; National Institute of Allergy and Infectious Diseases; University of Pittsburgh","keywords":"Cytotoxic T cell; Granzyme; Granzyme B; CD8; Immunology; Biology; T cell; Adoptive cell transfer; Immune system; Perforin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004859968,0.0002658813,0.0002826184,0.0007100833,0.0004769212,0.0000362899,0.0001557875,0.0003217573,0.0004685421],"category_scores_gemma":[0.00009488376,0.0002784948,0.0001725438,0.000819139,0.0001081026,0.0004963223,0.00009786907,0.0008179013,0.004599439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499484,"about_ca_system_score_gemma":0.00005777368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004963774,"about_ca_topic_score_gemma":0.0001042318,"domain_scores_codex":[0.9980205,0.0003732931,0.0005156175,0.0004810856,0.00006206924,0.0005473854],"domain_scores_gemma":[0.9992525,0.00005706474,0.0001769419,0.000416057,0.00007661262,0.0000208358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000490172,0.0001480514,0.003474389,0.00002779618,0.0001012078,0.00001346248,0.0005959872,0.00005708,0.9824836,0.00001855138,0.01199168,0.0005980766],"study_design_scores_gemma":[0.001822927,0.0003635559,0.1448054,0.00005488615,0.00005683341,0.0000801172,0.0003593485,0.000004537795,0.814195,0.00003121952,0.03788897,0.0003372105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843356,0.0005703575,0.00001403737,0.0001748629,0.01208494,0.0004160007,0.000005561211,0.000567512,0.00183112],"genre_scores_gemma":[0.9695126,0.0003467734,0.000005629102,0.00006026545,0.0001214676,0.0001117804,0.0002076286,0.00004256952,0.02959126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1682886,"threshold_uncertainty_score":0.9999667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087172906115616,"score_gpt":0.2441427216197362,"score_spread":0.2332709925585801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}