{"id":"W4389083298","doi":"10.1016/j.chembiol.2023.10.026","title":"Discovery of antibiotics that selectively kill metabolically dormant bacteria","year":2023,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Defense Threat Reduction Agency; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Volkswagen Foundation; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; Broad Institute; National Sleep Foundation; National Cancer Institute; National Science Foundation; James S. McDonnell Foundation; Harvard University","keywords":"Antibiotics; Bacteria; Biology; Microbiology; Drug discovery; Acinetobacter baumannii; Lipopolysaccharide; Bacterial cell structure; Toxicity; Computational biology; Biochemistry; Chemistry; Pseudomonas aeruginosa; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234012,0.0005219006,0.0004546601,0.000403144,0.0001709859,0.0006104987,0.0004007891,0.0007296031,0.0007701288],"category_scores_gemma":[0.0002948967,0.0002832264,0.0002480657,0.0001800333,0.000269585,0.0003418923,0.0002670025,0.0008815679,0.0004060504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004073566,"about_ca_system_score_gemma":0.000232312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003116232,"about_ca_topic_score_gemma":0.001014941,"domain_scores_codex":[0.9998462,0.00002019797,0.00001010168,0.00002317786,0.00006110811,0.00003910647],"domain_scores_gemma":[0.9998717,0.00002902608,0.00003198617,0.00001275378,0.00002449884,0.00002999497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008054361,0.00003479875,0.0001467212,0.00004699846,0.000006458201,0.00007790438,0.000008721668,0.0001219571,0.9907271,0.0003892365,0.0001992211,0.008160366],"study_design_scores_gemma":[0.00002873733,0.0002640442,0.0006735692,0.000007696991,0.00001717977,0.0003450153,0.00001154189,0.0006594985,0.990469,0.00008702827,0.007431553,0.000005036567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9365294,0.01827436,0.03343202,0.001650368,0.0003291258,0.0002350961,0.0007971871,0.0006759505,0.008076455],"genre_scores_gemma":[0.9597458,0.0105927,0.02034273,0.0005403733,0.00007906768,0.0001070603,0.0007178459,0.00008960652,0.007784794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007701288,"threshold_uncertainty_score":0.002955556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008860781114395824,"score_gpt":0.2552084144505103,"score_spread":0.2463476333361145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}