{"id":"W4389087702","doi":"10.1186/s12943-023-01906-8","title":"Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Uppsala Multidisciplinary Center for Advanced Computational Science; Instituto de Salud Carlos III; Govern de les Illes Balears; Fundación Francisco Cobos; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fundación Científica Asociación Española Contra el Cáncer; European Commission; Science for Life Laboratory; Fashion Footwear Association of New York","keywords":"Biology; CTCF; Cancer research; MMP1; Triple-negative breast cancer; Gene expression; Regulation of gene expression; Gene signature; Breast cancer; Gene; Cancer; Genetics; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067977,0.0001164233,0.0001124592,0.0001612116,0.0001049183,0.0002940404,0.00009231447,0.0001301433,0.000987856],"category_scores_gemma":[0.0001665654,0.0000889435,0.0001311848,0.0001040979,0.0001734814,0.0001177792,0.000259521,0.0002377216,0.0002153445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154778,"about_ca_system_score_gemma":0.0001276945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004816332,"about_ca_topic_score_gemma":0.0008661737,"domain_scores_codex":[0.9999135,0.000008842311,0.0000038987,0.00003028701,0.00001950392,0.00002392411],"domain_scores_gemma":[0.9999008,0.00001960639,0.00003285959,0.000009862812,0.00001545032,0.00002133118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001311823,0.00001862034,0.01004753,0.00004623172,0.00001198985,0.00007517443,0.00007982116,0.0002114281,0.9840727,0.0002222232,0.0001438134,0.004939362],"study_design_scores_gemma":[0.00004175254,0.0004501878,0.4248528,0.00003431452,0.00007667043,0.001163679,0.0003462429,0.007855433,0.5530455,0.0008950121,0.01120995,0.00002853675],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944049,0.0009711396,0.002941336,0.00005227881,0.00001371334,0.00001268223,0.0003825519,0.0000932117,0.00112802],"genre_scores_gemma":[0.9978513,0.0002199274,0.0008798534,0.00003408064,0.000004625484,0.00001078837,0.0003751355,0.00001304043,0.0006113176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000987856,"threshold_uncertainty_score":0.00330472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009708155369060924,"score_gpt":0.2850596545848437,"score_spread":0.2753514992157828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}