{"id":"W4389087702","doi":"10.1186/s12943-023-01906-8","title":"Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Uppsala Multidisciplinary Center for Advanced Computational Science; Instituto de Salud Carlos III; Govern de les Illes Balears; Fundación Francisco Cobos; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Fundación Científica Asociación Española Contra el Cáncer; European Commission; Science for Life Laboratory; Fashion Footwear Association of New York","keywords":"Biology; CTCF; Cancer research; MMP1; Triple-negative breast cancer; Gene expression; Regulation of gene expression; Gene signature; Breast cancer; Gene; Cancer; Genetics; Enhancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262024,0.0002470536,0.0002100708,0.0001290234,0.00008083871,0.00004473945,0.0001781089,0.0001981064,0.00005733311],"category_scores_gemma":[0.0000530607,0.0002341986,0.0001137454,0.0004028427,0.00004309186,0.00001776026,0.00017683,0.0001409642,0.00001716225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006761201,"about_ca_system_score_gemma":0.0001704961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004047167,"about_ca_topic_score_gemma":0.00005409097,"domain_scores_codex":[0.9983093,0.0001177328,0.0003119877,0.0005936,0.0002486052,0.0004187601],"domain_scores_gemma":[0.999195,0.00000490397,0.0002206964,0.0003885349,0.00008768525,0.0001031264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096601,0.00003572147,0.0005227344,0.00005154882,0.00003542728,0.0001330723,0.00006312832,0.001669624,0.9928772,0.00001518403,0.0002301096,0.00425653],"study_design_scores_gemma":[0.0007623878,0.00006032714,0.00242202,0.0002749307,0.00002206589,0.00002353941,0.00004077771,0.001111169,0.9942273,0.0001993391,0.0005510525,0.0003050414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938598,0.003910144,0.0008897748,0.0003613727,0.0001774384,0.0006372169,0.00005984156,0.00005879093,0.00004566699],"genre_scores_gemma":[0.9968383,0.0003244312,0.0008169053,0.0002086645,0.0002389559,0.001059327,0.0002122636,0.00005908494,0.0002420212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003951489,"threshold_uncertainty_score":0.955034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009708155369060924,"score_gpt":0.2850596545848437,"score_spread":0.2753514992157828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}