{"id":"W4389089882","doi":"10.1186/s13048-023-01313-z","title":"BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy","year":2023,"lang":"en","type":"article","venue":"Journal of Ovarian Research","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Ottawa Hospital Research Institute; Canadian Institutes of Health Research; Health Canada; Ovarian Cancer Canada; University of Ottawa","keywords":"Olaparib; Medicine; Ovarian cancer; Cancer research; Immune system; Angiogenesis; Tumor microenvironment; Immunotherapy; Combination therapy; Oncology; Cancer; Immunology; Internal medicine; Biology; Gene; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001818766,0.0002430367,0.0005206174,0.0007988537,0.0003363936,0.000225065,0.0001834489,0.00009574591,0.0001381929],"category_scores_gemma":[0.0001587125,0.0001793458,0.0001165411,0.0005526741,0.000151701,0.0001369367,0.0002306463,0.0005171908,0.00003500838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586858,"about_ca_system_score_gemma":0.0002830385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000915004,"about_ca_topic_score_gemma":0.00001026684,"domain_scores_codex":[0.9968776,0.0003896426,0.000552526,0.0004482758,0.0010881,0.0006438432],"domain_scores_gemma":[0.9983356,0.0003043144,0.0001437023,0.0003020275,0.0002203004,0.000694048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.029536,0.005072681,0.2077678,0.0004347622,0.003656439,0.01463969,0.007814419,0.0005628864,0.5911347,0.004073179,0.04165762,0.09364987],"study_design_scores_gemma":[0.006920456,0.002426954,0.9767288,0.0002769724,0.0001098627,0.0007629411,0.0002815848,0.0009129284,0.007338167,0.001006003,0.003027983,0.0002073449],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862062,0.001152203,0.0003201943,0.01127422,0.0001884745,0.0005804315,0.00004762565,0.00001665613,0.0002139445],"genre_scores_gemma":[0.9946064,0.002994648,0.001016007,0.0001779593,0.0004153016,0.00003492734,0.000008195138,0.00005005849,0.0006965199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.768961,"threshold_uncertainty_score":0.7313511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1185263670335147,"score_gpt":0.3749950771103623,"score_spread":0.2564687100768476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}