{"id":"W4389091353","doi":"10.33590/emjgastroenterol/10303980","title":"Challenges in Management of Immune Checkpoint Inhibitor-Associated Hepatitis","year":2023,"lang":"en","type":"article","venue":"EMJ Gastroenterology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University Health Network","funders":"","keywords":"Medicine; Colorectal cancer; Cancer; Pembrolizumab; Internal medicine; Oncology; Immunology; Gastroenterology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002280187,0.0003986527,0.001007206,0.0007418936,0.001026847,0.002257265,0.0006777223,0.001779234,0.00344374],"category_scores_gemma":[0.005254513,0.0001893554,0.0006019949,0.0002944264,0.0006807555,0.002140589,0.001487228,0.005458954,0.001116808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001043241,"about_ca_system_score_gemma":0.001803524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365909,"about_ca_topic_score_gemma":0.002533235,"domain_scores_codex":[0.9989512,0.0003743768,0.0001522423,0.0001340642,0.0002171818,0.000170889],"domain_scores_gemma":[0.9980912,0.0006253067,0.0002465676,0.00006132797,0.000424754,0.000550933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003614421,0.000452022,0.02696208,0.0009585819,0.0001589868,0.01042158,0.0005314521,0.001212725,0.00173598,0.006589981,0.1354964,0.8151188],"study_design_scores_gemma":[0.000396486,0.002161582,0.08766711,0.01440611,0.000342244,0.06585255,0.006685656,0.005652593,0.001809984,0.04101375,0.7737635,0.0002485058],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03981688,0.346075,0.01591212,0.5392067,0.01405535,0.0002075763,0.0003112332,0.0003483171,0.04406682],"genre_scores_gemma":[0.4884774,0.2371335,0.03456112,0.1427461,0.08034223,0.0003978015,0.0008880842,0.0002108707,0.01524294],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00344374,"threshold_uncertainty_score":0.01205897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03191322957300105,"score_gpt":0.2795448989157016,"score_spread":0.2476316693427005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}