{"id":"W4389092954","doi":"10.3389/fcvm.2023.1273596","title":"Role of vascular smooth muscle cell clonality in atherosclerosis","year":2023,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"Progenitor cell; Biology; Disease; Inflammation; Phenotype; Cell type; Stem cell; clone (Java method); Mural cell; Cell; Vascular smooth muscle; Smooth muscle; Immunology; Neuroscience; Pathology; Cell biology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001865638,0.0005472242,0.003183131,0.0004022944,0.00003069228,0.00000720421,0.0006059642,0.0007643119,0.000008068296],"category_scores_gemma":[0.0001350198,0.0004811674,0.002085978,0.0007644917,0.0002540788,0.000004282984,0.0001285419,0.0004697701,0.000004887575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139085,"about_ca_system_score_gemma":0.0002047485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006550445,"about_ca_topic_score_gemma":0.00007053965,"domain_scores_codex":[0.996425,0.0005396312,0.001068031,0.0009035543,0.0005810182,0.0004827564],"domain_scores_gemma":[0.9982394,0.00002997869,0.0002229946,0.001321698,0.00006743975,0.0001184889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002916105,0.0002483192,0.002235114,0.01602433,0.002352432,0.00002874157,0.0002479961,0.0002204999,0.001477216,0.00000484716,0.0016447,0.9754866],"study_design_scores_gemma":[0.001492887,0.0001273539,0.001637747,0.005151908,0.001188586,0.000001721604,0.0001673752,0.00001954491,0.0001191861,0.00004586438,0.9895641,0.0004837014],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007908159,0.9958166,0.001129182,0.000005264324,0.000963741,0.0008046472,0.00005561594,0.00001889172,0.000415205],"genre_scores_gemma":[0.0008826432,0.9972536,0.0005952818,0.00002228552,0.0004651509,0.0001168361,0.0004521724,0.0001398638,0.00007216477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9879194,"threshold_uncertainty_score":0.999764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848171270247368,"score_gpt":0.2586940838263745,"score_spread":0.2302123711239008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}